Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5398970 | 0.82 | CTSS (0.41) | EPHX1CTSSFPR2MAPTPLA2G1B | |
| SCHEMBL3024779 | 0.77 | CTSS (0.49) | EPHX1CTSSCTSLCTSKFPR2 | |
| SCHEMBL6685716 | 0.75 | KDM4E (0.47) | EPHX1CTSSCTSLCTSKPOLB | |
| SCHEMBL5500899 | 0.71 | EPHX1 (0.52) | EPHX1CTSSCTSLCTSKFPR2 | |
| SCHEMBL24327967 | 0.69 | FPR2 (0.52) | FPR2MAPTPLA2G1BSMN1; SMN2ATG4B | |
| SCHEMBL6691065 | 0.69 | RAB9A (0.45) | CTSSCTSKMAPTSMN1; SMN2KMT2A | |
| SCHEMBL3024781 | 0.68 | CTSS (0.67) | CTSSCTSLCTSKACE | |
| SCHEMBL6689992 | 0.67 | CFD (0.41) | EPHX1POLBEPHX2 | |
| SCHEMBL9422891 | 0.66 | ACHE (0.61) | MAPTPLA2G1BSMN1; SMN2ATG4BHTT | |
| SCHEMBL6688710 | 0.65 | POLB (0.43) | EPHX1MAPTHDAC1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658267-A4 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-08-01 | — | — | EP | disclosed |
| EP-1658267-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005034848-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2005-04-21 | — | — | WO | disclosed |