Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5266671 | 0.86 | POLB (0.41) | POLBMAPTGAAALDH1A1KDM4E | |
| SCHEMBL5506452 | 0.85 | ALDH1A1 (0.48) | POLBMAPTGAAALDH1A1KDM4E | |
| SCHEMBL5510893 | 0.84 | PPARD (0.39) | POLBMAPTGAAALDH1A1KDM4E | |
| SCHEMBL5504449 | 0.84 | ALOX5 (0.39) | POLBMAPTALOX5MEN1KMT2A | |
| SCHEMBL5519196 | 0.84 | CSF1R (0.38) | POLBMAPTALDH1A1HPGDALOX5 | |
| SCHEMBL5505103 | 0.83 | LMNA (0.39) | MAPTGAAALDH1A1KDM4EHPGD | |
| SCHEMBL5510025 | 0.82 | LGALS8 (0.38) | POLBMAPTALOX5MEN1KMT2A | |
| SCHEMBL5503551 | 0.80 | LMNA (0.39) | MAPTKDM4EHPGDLMNAL3MBTL1 | |
| SCHEMBL5512279 | 0.79 | TLR9 (0.38) | MAPTGAAALDH1A1ALOX5AR | |
| SCHEMBL5507785 | 0.78 | ALOX5 (0.42) | MAPTGAAALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841735-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006077366-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2006-07-27 | — | — | WO | disclosed |