Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ILK | Q13418 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502924 | 0.84 | KDM4E (0.52) | NCF1CYP1A2CYP3A4TP53CYP2D6 | |
| SCHEMBL5502143 | 0.82 | NCF1 (0.50) | NCF1CYP1A2CYP3A4TP53CYP2D6 | |
| SCHEMBL16416202 | 0.72 | HTR6 (0.63) | NCF1CYP1A2CYP3A4TP53CYP2D6 | |
| SCHEMBL3679159 | 0.71 | HTR1A (0.53) | NCF1CYP1A2CYP3A4TP53CYP2D6 | |
| SCHEMBL1222766 | 0.71 | CYP1A2 (0.76) | NCF1CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL16416324 | 0.71 | SLC2A1 (0.54) | KMT2AMEN1KDM4EMTNR1BHTR6 | |
| SCHEMBL8917174 | 0.70 | HRH4 (0.38) | CYP2D6TSHRCLK4KDM4EALDH1A1 | |
| SCHEMBL4190466 | 0.69 | NCF1 (0.56) | NCF1KMT2AMEN1KDM4EHTR3E | |
| Trifluoroacetic Acid SCHEMBL30619102 | 0.69 | NCF1 (0.50) | NCF1CYP1A2CYP3A4TP53CYP2D6 | |
| SCHEMBL2708405 | 0.69 | ADRB2 (0.72) | NCF1CYP1A2CYP3A4TP53CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218353-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2007-10-17 | — | — | EP | disclosed |
| EP-1272185-B1 | USE OF QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |