Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5573431 | 0.85 | MCHR1 (0.37) | GPR35MCHR1GCKPTPN5SCN9A | |
| SCHEMBL5570207 | 0.85 | GPR35 (0.36) | GPR35MCHR1GCKPTPN5ALOX5AP | |
| SCHEMBL5509633 | 0.83 | DGAT1 (0.35) | GPR35MCHR1PTPN5ALOX5APFEN1 | |
| SCHEMBL5506955 | 0.82 | KMT2A (0.39) | PTPN11RXRARXRBMCHR1GCK | |
| SCHEMBL5509248 | 0.80 | MCL1 (0.40) | GPR35GCKPPARDDGAT1 | |
| SCHEMBL5267329 | 0.80 | MCHR1 (0.35) | MCHR1PTPN5SCN9APPARDDGAT1 | |
| SCHEMBL5272120 | 0.79 | MCHR1 (0.34) | MCHR1PTPN5SCN9APPARDDGAT1 | |
| SCHEMBL5574783 | 0.78 | KDM4E (0.44) | MCHR1GCKPPARDDGAT1 | |
| SCHEMBL5574008 | 0.78 | MCHR1 (0.34) | GPR35MCHR1GCKSCN9APPARD | |
| SCHEMBL5571405 | 0.77 | KDM4E (0.43) | MCHR1GCKPPARDDGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841735-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006077366-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2006-07-27 | — | — | WO | disclosed |