Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11720741 | 0.76 | PGR (0.69) | HTTLMNAHPGDMAPK1ALDH1A1 | |
| SCHEMBL9204684 | 0.72 | ALDH1A1 (0.49) | HTTLMNAHPGDMAPK1ALDH1A1 | |
| SCHEMBL5508801 | 0.71 | ADORA3 (0.83) | HTTLMNAHPGDMAPK1ALDH1A1 | |
| SCHEMBL5512557 | 0.71 | ALDH1A1 (0.44) | HTTLMNAHPGDMAPK1ALDH1A1 | |
| SCHEMBL29360167 | 0.71 | ALDH1A1 (0.75) | HTTLMNAHPGDMAPK1ALDH1A1 | |
| SCHEMBL151563 | 0.71 | ALDH1A1 (0.75) | HTTLMNAHPGDMAPK1ALDH1A1 | |
| SCHEMBL29963695 | 0.71 | ALDH1A1 (0.75) | HTTLMNAHPGDMAPK1ALDH1A1 | |
| SCHEMBL9209660 | 0.70 | LMNA (0.53) | HTTLMNAHPGDMAPK1ALDH1A1 | |
| Formaldehyde SCHEMBL27505377 | 0.69 | ALDH1A1 (0.73) | HTTLMNAHPGDMAPK1ALDH1A1 | |
| SCHEMBL12498669 | 0.69 | ALDH1A1 (0.72) | HTTLMNAHPGDMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863813-A2 | PYRAZOLO[3,4-C]QUINOLINES, PYRAZOLO[3,4-C]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107771-A2 | PYRAZOLO[3,4-c]QUINOLINES, PYRAZOLO[3,4-c]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |