Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 6/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.59 |
| ▸ | CCR3 | P51677 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.53 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.53 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.53 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.53 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5974096 | 0.99 | GRIN2B (0.58) | GRIN2BGRIN2AGRIN1GRIN2DGRIN3B | |
| SCHEMBL7367603 | 0.88 | MAPK1 (0.57) | GRIN2BGRIN2AGRIN1GRIN2DGRIN3B | |
| SCHEMBL7395591 | 0.82 | CCR3 (0.55) | GRIN2BGRIN2ACCR3SIGMAR1PRMT3 | |
| SCHEMBL5047712 | 0.82 | MMP2 (0.44) | GRIN2BGRIN2AGRIN1GRIN2DGRIN3B | |
| SCHEMBL5505396 | 0.82 | MMP2 (0.44) | GRIN2BGRIN2AGRIN1GRIN2DGRIN3B | |
| SCHEMBL5047717 | 0.82 | MMP2 (0.44) | GRIN2BGRIN2AGRIN1GRIN2DGRIN3B | |
| SCHEMBL24069354 | 0.82 | PRMT6 (0.56) | GRIN2BGRIN2AGRIN1GRIN2DGRIN3B | |
| SCHEMBL15423952 | 0.80 | MEN1 (0.76) | GRIN2BGRIN2AGRIN1GRIN2DGRIN3B | |
| SCHEMBL4632689 | 0.80 | CARM1 (0.53) | CCR3SIGMAR1PRMT3CARM1PRMT6 | |
| SCHEMBL25758336 | 0.80 | MEN1 (0.62) | CCR3SIGMAR1PRMT3CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1332363-A4 | DETECTION OF NEURODEGENERATIVE DISORDERS | DOUBLE KAY (AU) | 2007-08-29 | — | — | EP | claimed |
| EP-1189886-B1 | ETHANESULFONYL-PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-01-04 | — | — | EP | claimed |
| US-20050260577-A1 | Detection of neurodegenerative disorders | POWMRI LIMITED (AU) | 2005-11-24 | — | — | US | claimed |
| CN-1142141-C | Ethanesulfonyl-piperidine derivatives | - | 2004-03-17 | — | — | CN | claimed |
| EP-1332363-A1 | DETECTION OF NEURODEGENERATIVE DISORDERS | UNISEARCH LIMITED (AU) | 2003-08-06 | — | — | EP | claimed |
| CN-1354745-A | Ethanesulfonyl-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2002-06-19 | — | — | CN | claimed |
| WO-2002031499-A1 | DETECTION OF NEURODEGENERATIVE DISORDERS | UNISEARCH LIMITED (AU) | 2002-04-18 | — | — | WO | claimed |
| EP-1189886-A1 | ETHANESULFONYL-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-27 | — | — | EP | claimed |
| US-6310213-B1 | GOOD AFFITITY TO THE NMDA RECEPTOR AND THEY ARE THEREFORE USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | claimed |
| WO-2000075109-A1 | ETHANESULFONYL-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-14 | — | — | WO | claimed |
| EP-1332363-A4 | DETECTION OF NEURODEGENERATIVE DISORDERS | DOUBLE KAY (AU) | 2007-08-29 | — | — | EP | disclosed |
| EP-1189886-B1 | ETHANESULFONYL-PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-01-04 | — | — | EP | disclosed |
| US-20050260577-A1 | Detection of neurodegenerative disorders | POWMRI LIMITED (AU) | 2005-11-24 | — | — | US | disclosed |
| CN-1142141-C | Ethanesulfonyl-piperidine derivatives | - | 2004-03-17 | — | — | CN | disclosed |
| EP-1332363-A1 | DETECTION OF NEURODEGENERATIVE DISORDERS | UNISEARCH LIMITED (AU) | 2003-08-06 | — | — | EP | disclosed |
| CN-1354745-A | Ethanesulfonyl-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2002-06-19 | — | — | CN | disclosed |
| WO-2002031499-A1 | DETECTION OF NEURODEGENERATIVE DISORDERS | UNISEARCH LIMITED (AU) | 2002-04-18 | — | — | WO | disclosed |
| EP-1189886-A1 | ETHANESULFONYL-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-27 | — | — | EP | disclosed |
| US-6310213-B1 | GOOD AFFITITY TO THE NMDA RECEPTOR AND THEY ARE THEREFORE USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |
| WO-2000075109-A1 | ETHANESULFONYL-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-14 | — | — | WO | disclosed |