Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 4/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | MC3R | P41968 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1F | P30939 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6688690 | 1.00 | OPRL1 (0.34) | OPRL1IDO1PIM1PIM2DPP9 | |
| SCHEMBL6696331 | 0.82 | CTSS (0.37) | PIM1PIM2NPC1POLBRAB9A | |
| SCHEMBL5497651 | 0.81 | CTSS (0.40) | PIM1PIM2NPC1POLBRAB9A | |
| SCHEMBL6685697 | 0.78 | TRPV1 (0.35) | IDO1CTSLHTR1AHTR1DHTR1F | |
| SCHEMBL6687531 | 0.77 | TRPV1 (0.34) | IDO1PYGL | |
| SCHEMBL6689424 | 0.77 | TRPV1 (0.34) | IDO1PYGL | |
| SCHEMBL6693432 | 0.76 | CTSS (0.41) | CTSL | |
| SCHEMBL6686987 | 0.76 | CTSL (0.42) | NPC1POLBRAB9APYGLCTSL | |
| SCHEMBL6686227 | 0.75 | CTSS (0.40) | POLBCTSL | |
| SCHEMBL6689091 | 0.75 | CTSL (0.41) | NPC1POLBRAB9ACTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658267-A4 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-08-01 | — | — | EP | disclosed |
| EP-1658267-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005034848-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2005-04-21 | — | — | WO | disclosed |