Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.40 |
| ▸ | CTSL | P07711 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | METAP1 | P53582 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6696331 | 0.89 | CTSS (0.37) | CTSSCTSLRAB9ANPC1METAP2 | |
| SCHEMBL6693432 | 0.84 | CTSS (0.41) | CTSSCTSLCTSK | |
| SCHEMBL6688690 | 0.81 | OPRL1 (0.34) | CTSLRAB9ANPC1PIM1PIM2 | |
| SCHEMBL5505729 | 0.81 | OPRL1 (0.34) | CTSLRAB9ANPC1PIM1PIM2 | |
| SCHEMBL6689460 | 0.80 | MMP3 (0.40) | CTSSCTSL | |
| SCHEMBL6690381 | 0.80 | CTSS (0.46) | CTSSCTSLCTSK | |
| SCHEMBL6690326 | 0.80 | CTSS (0.45) | CTSSCTSLCTSK | |
| SCHEMBL6690633 | 0.79 | USP30 (0.40) | CTSSCTSLCTSK | |
| SCHEMBL6690630 | 0.79 | USP30 (0.41) | CTSSCTSLCTSK | |
| SCHEMBL6686203 | 0.78 | BMP1 (0.42) | CTSSCTSLNPC1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658267-A4 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-08-01 | — | — | EP | disclosed |
| EP-1658267-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005034848-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2005-04-21 | — | — | WO | disclosed |