Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.42 |
| ▸ | RXRB | P28702 | 7/20 | 0.42 |
| ▸ | RXRG | P48443 | 7/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505765 | 0.91 | PTGDR2 (0.44) | RXRARXRBRXRGTHRBPPARD | |
| SCHEMBL5504469 | 0.91 | PPARD (0.41) | THRBPPARDFFAR1PPARA | |
| SCHEMBL5502236 | 0.89 | FFAR1 (0.38) | THRBPPARDFFAR1PPARGPPARA | |
| SCHEMBL5517204 | 0.80 | TOP1 (0.34) | RXRARXRBRXRGPPARDSMN1; SMN2 | |
| SCHEMBL5501032 | 0.80 | THRA (0.40) | RXRARXRBRXRGTHRBPPARD | |
| SCHEMBL5267628 | 0.80 | PPARD (0.39) | RXRARXRBRXRGPPARDFFAR1 | |
| SCHEMBL5502096 | 0.79 | BRD4 (0.39) | PPARD | |
| SCHEMBL5502760 | 0.79 | MAP2 (0.39) | FFAR1PPARA | |
| SCHEMBL5502589 | 0.78 | EGLN1 (0.39) | THRBPPARDFFAR1PPARGPPARA | |
| SCHEMBL5506365 | 0.77 | LGALS8 (0.41) | THRBPPARDFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841735-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006077366-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2006-07-27 | — | — | WO | disclosed |