Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18917601 | 0.84 | SLC6A3 (0.77) | SLC6A3DRD2SLC6A4LTA4HSIGMAR1 | |
| SCHEMBL5501121 | 0.84 | HRH1 (0.58) | SLC6A3SLC6A4LTA4HSIGMAR1HRH3 | |
| SCHEMBL28610633 | 0.82 | PRMT6 (0.63) | HRH3ALDH1A1KDM4E | |
| SCHEMBL7111066 | 0.78 | HRH3 (0.47) | SLC6A3DRD2SLC6A4SIGMAR1HRH3 | |
| SCHEMBL3218005 | 0.77 | SIGMAR1 (0.75) | SLC6A3DRD2SLC6A4LTA4HSIGMAR1 | |
| SCHEMBL18798802 | 0.77 | LMNA (0.50) | SLC6A3 | |
| SCHEMBL872805 | 0.76 | HTR7 (0.66) | SLC6A3DRD2SLC6A4LTA4HSIGMAR1 | |
| SCHEMBL3216167 | 0.76 | SIGMAR1 (0.73) | SLC6A3DRD2SLC6A4LTA4HSIGMAR1 | |
| SCHEMBL10339219 | 0.76 | CA2 (0.54) | ALDH1A1KDM4E | |
| SCHEMBL5499377 | 0.75 | HRH3 (0.61) | SLC6A3SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817294-A1 | 1,2,3,4-TETRAHYDROPYRAZIN-2-YL ACETAMIDES AND THEIR USE AS BRADYKININ ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION RELATED DISORDERS | Amgen Inc. (US) | 2007-08-15 | — | — | EP | claimed |
| WO-2006019975-A1 | 1,2,3,4-TETRAHYDROPYRAZIN-2-YL ACETAMIDES AND THEIR USE AS BRADYKININ ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION RELATED DISORDERS | AMGEN INC. (US) | 2006-02-23 | — | — | WO | claimed |