Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5508579 | 1.00 | ALDH1A1 (0.47) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL5507933 | 0.78 | KCNH2 (0.45) | ALDH1A1MEN1KMT2ACNR1CNR2 | |
| SCHEMBL5509547 | 0.78 | CYP2C9 (0.45) | ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL5506636 | 0.77 | KCNH2 (0.56) | KMT2AMCHR1 | |
| SCHEMBL5514123 | 0.76 | KCNH2 (0.55) | — | |
| SCHEMBL5511934 | 0.75 | ROCK2 (0.46) | ALDH1A1MEN1KMT2ATSHRCNR1 | |
| SCHEMBL14372276 | 0.73 | KCNH2 (0.44) | ALDH1A1POLBCNR1CNR2 | |
| SCHEMBL5267677 | 0.72 | SLC2A1 (0.47) | CNR1CNR2 | |
| SCHEMBL5267681 | 0.72 | SLC2A1 (0.47) | CNR1CNR2 | |
| SCHEMBL5514132 | 0.72 | KCNH2 (0.35) | ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | claimed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | claimed |