Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5508574 | 0.78 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1TDP1L3MBTL1 | |
| SCHEMBL5508579 | 0.78 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1TDP1L3MBTL1 | |
| SCHEMBL5514123 | 0.77 | KCNH2 (0.55) | KCNH2SLC2A1 | |
| SCHEMBL5509547 | 0.75 | CYP2C9 (0.45) | KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL5506636 | 0.75 | KCNH2 (0.56) | KCNH2KMT2A | |
| SCHEMBL5514132 | 0.74 | KCNH2 (0.35) | KCNH2MEN1KMT2AALDH1A1SLC2A1 | |
| SCHEMBL5511934 | 0.73 | ROCK2 (0.46) | KCNH2MEN1KMT2AALDH1A1CNR1 | |
| SCHEMBL6797927 | 0.68 | KDM4E (0.42) | KCNH2 | |
| SCHEMBL3248823 | 0.67 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL5250858 | 0.67 | KCNH2 (0.55) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | claimed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | claimed |
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |