Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2960574 | 0.74 | NCOA3 (0.37) | CYP19A1MAPTCYP11B1CYP11B2LMNA | |
| SCHEMBL20508344 | 0.73 | SMN1; SMN2 (0.34) | CYP19A1MAPTLMNATP53HPGD | |
| SCHEMBL38659921 | 0.72 | CYP19A1 (0.40) | SLC6A2CYP19A1MAPTCYP11B1CYP11B2 | |
| SCHEMBL4756741 | 0.72 | CYP19A1 (0.40) | SLC6A2CYP19A1MAPTCYP11B1CYP11B2 | |
| SCHEMBL4499485 | 0.72 | MAPT (0.38) | SLC6A2CYP19A1MAPTLMNA | |
| SCHEMBL4503239 | 0.72 | MAPT (0.41) | SLC6A2CYP19A1MAPTCYP11B1CYP11B2 | |
| SCHEMBL64923 | 0.71 | ALDH1A1 (0.42) | MAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL30307422 | 0.71 | ALDH1A1 (0.42) | MAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL1599024 | 0.71 | CYP11B2 (0.47) | CYP11B2LCKHPGDHSD17B10 | |
| SCHEMBL29505892 | 0.71 | CYP11B2 (0.47) | CYP11B2LCKHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920148-B1 | PICTET-SPENGLER LIGATION FOR PROTEIN CHEMICAL MODIFICATION | UNIV CALIFORNIA (US) | 2019-06-12 | — | — | EP | disclosed |
| US-9605078-B2 | Pictet-Spengler ligation for protein chemical modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150291699-A1 | PICTET-SPENGLER LIGATION FOR PROTEIN CHEMICAL MODIFICATION | GERAWAN FARMING LLC | 2015-10-15 | — | — | US | disclosed |
| EP-2920148-A1 | PICTET-SPENGLER LIGATION FOR PROTEIN CHEMICAL MODIFICATION | The Regents of The University of California (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014121417-A1 | TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C | MERCK SHARP & DOHME CORP. (US) | 2014-08-14 | — | — | WO | disclosed |
| WO-2014078733-A1 | PICTET-SPENGLER LIGATION FOR PROTEIN CHEMICAL MODIFICATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-05-22 | — | — | WO | disclosed |
| EP-1756102-A1 | 8-PHENOXY-GammaCARBOLINE DERIVATIVES | Pharma C S.A. (FR) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005095396-A1 | 8-PHENOXY-Ϝ CARBOLINE DERIVATIVES | PHARMA C S.A. (FR) | 2005-10-13 | — | — | WO | disclosed |
| EP-0072346-B1 | AMIDINES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOUNDS CONTAINING THEM AND THEIR USE | CIBA-GEIGY AG (CH) | 1986-04-09 | — | — | EP | disclosed |
| US-4444768-A | ICE CREAM CONE WRAPPER | CIBA-GEIGY CORPORATION (US) | 1984-04-24 | — | — | US | disclosed |
| US-4307234-A | Pyrimido[1,6-a]indole derivatives | AMERICAN HOME PRODUCTS CORP. (US) | 1981-12-22 | — | — | US | disclosed |
| US-4307234-A | Pyrimido[1,6-a]indole derivatives | AMERICAN HOME PRODUCTS CORP. (US) | 1981-12-22 | — | — | US | disclosed |
| US-4307234-A | Pyrimido[1,6-a]indole derivatives | AMERICAN HOME PRODUCTS CORP. (US) | 1981-12-22 | — | — | US | disclosed |
| EP-0035474-A1 | Amidines, process for their production, pharmaceutical preparations containing them and their use | CIBA-GEIGY AG (CH) | 1981-09-09 | — | — | EP | disclosed |
| EP-0008950-A3 | PYRIMIDO(1,6-A)INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES AND THEIR USE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-06-11 | — | — | EP | disclosed |
| EP-0008950-A3 | PYRIMIDO(1,6-A)INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES AND THEIR USE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-06-11 | — | — | EP | disclosed |
| WO-1980000537-A1 | PYRIMIDO(1,6-A)INDOLE DERIVATIVES | AMERICAN HOME PROD (US) | 1980-04-03 | — | — | WO | disclosed |
| EP-0008950-A2 | Pyrimido(1,6-a)indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing the derivatives and their use | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-03-19 | — | — | EP | disclosed |
| EP-0008950-A2 | Pyrimido(1,6-a)indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing the derivatives and their use | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-03-19 | — | — | EP | disclosed |
| EP-0008950-A2 | Pyrimido(1,6-a)indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing the derivatives and their use | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291699-A1 | PICTET-SPENGLER LIGATION FOR PROTEIN CHEMICAL MODIFICATION | PTMS, SHMT1, OGA | SLC6A2 1529/4885CYP19A1 1299/4885MAPT 1429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.