Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38659921 | 1.00 | CYP19A1 (0.40) | CYP19A1CYP11B1CYP11B2MAPTKDM4E | |
| Fumaric Acid SCHEMBL9431713 | 0.87 | SLC6A2 (0.40) | CYP19A1KDM4EALDH1A1HPGDSLC6A2 | |
| Fumaric Acid SCHEMBL9431708 | 0.87 | SLC6A2 (0.40) | CYP19A1KDM4EALDH1A1HPGDSLC6A2 | |
| SCHEMBL9430919 | 0.76 | CYP11B2 (0.38) | CYP19A1CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL5728067 | 0.75 | KDM4E (0.40) | CYP19A1CYP11B1CYP11B2MAPTKDM4E | |
| SCHEMBL30307422 | 0.74 | ALDH1A1 (0.42) | MAPTKDM4EGAAALDH1A1GLA | |
| SCHEMBL64923 | 0.74 | ALDH1A1 (0.42) | MAPTKDM4EGAAALDH1A1GLA | |
| SCHEMBL4499485 | 0.74 | MAPT (0.38) | CYP19A1MAPTKDM4ESLC6A2IDO1 | |
| SCHEMBL4503239 | 0.74 | MAPT (0.41) | CYP19A1CYP11B1CYP11B2MAPTKDM4E | |
| SCHEMBL20508344 | 0.72 | SMN1; SMN2 (0.34) | CYP19A1MAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2989105-B1 | PYRAZINO[1,2-A]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS SA (ES) | 2020-03-11 | — | — | EP | disclosed |
| EP-2989104-B1 | PYRAZINO[1,2-A]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS SA (ES) | 2019-08-21 | — | — | EP | disclosed |
| US-9963453-B2 | Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2018-05-08 | — | — | US | disclosed |
| US-9963453-B2 | Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2018-05-08 | — | — | US | disclosed |
| US-9879015-B2 | Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2018-01-30 | — | — | US | disclosed |
| US-9879015-B2 | Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2018-01-30 | — | — | US | disclosed |
| US-20160075709-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2016-03-17 | — | — | US | disclosed |
| US-20160060268-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2016-03-03 | — | — | US | disclosed |
| CN-105339369-A | Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments | ESTEVE LABOR DR | 2016-02-17 | — | — | CN | disclosed |
| CN-105263933-A | Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments | ESTEVE LABOR DR | 2016-01-20 | — | — | CN | disclosed |
| US-8343981-B2 | Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents | AICURIS GMBH & CO. KG (DE) | 2013-01-01 | — | — | US | disclosed |
| EP-1625129-B1 | HETEROCYCLYL-SUBSTITUTED DIHYDROQUINAZOLINES AND USE THEREOF AS AN ANTIVIRAL AGENT | BAYER HEALTHCARE AG (DE) | 2008-03-05 | — | — | EP | disclosed |
| US-20070185121-A1 | Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents | BAYER HEALTHCARE AG (DE) | 2007-08-09 | — | — | US | disclosed |
| US-7145009-B2 | Pirazino(aza)indole derivatives | VERNALIS RESEARCH LIMITED (GB) | 2006-12-05 | — | — | US | disclosed |
| US-20060160816-A1 | Pirazino(AZA) indole derivatives | VERNALIS RESEARCH LIMITED | 2006-07-20 | — | — | US | disclosed |
| US-6800627-B1 | CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS, DIABETES INSPIDUS, SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2004-10-05 | — | — | US | disclosed |
| US-20040092525-A1 | Pirazino(aza)indole derivatives | VERNALIS RESEARCH LIMITED | 2004-05-13 | — | — | US | disclosed |
| US-20040039200-A1 | Pirazino(AZA)indole derivatives | VERNALIS RESEARCH LIMITED | 2004-02-26 | — | — | US | disclosed |
| EP-1147110-B1 | PYRAZINO(AZA)INDOLE DERIVATIVES | VERNALIS RES LTD (GB) | 2003-05-07 | — | — | EP | disclosed |
| WO-1996012721-A1 | INDOLE DERIVATIVES USEFUL AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092525-A1 | Pirazino(aza)indole derivatives | PIR, GPR119, INMT | CYP19A1 249/4885CYP11B1 34/4885CYP11B2 29/4885 |
| US-20060160816-A1 | Pirazino(AZA) indole derivatives | PIR, GPR119, INMT | CYP19A1 367/4885CYP11B1 43/4885CYP11B2 28/4885 |
| US-20070185121-A1 | Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents | TYMP, RPL35, EIF2AK2 | CYP19A1 3895/4885CYP11B1 1817/4885CYP11B2 1187/4885 |
| US-20040039200-A1 | Pirazino(AZA)indole derivatives | PIR, GPR119, INMT | CYP19A1 249/4885CYP11B1 34/4885CYP11B2 29/4885 |
| US-20160060268-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | IDO1, TPH1, IDO2 | CYP19A1 814/4885CYP11B1 111/4885CYP11B2 61/4885 |
| US-20160075709-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | IDO1, TPH1, IDO2 | CYP19A1 814/4885CYP11B1 111/4885CYP11B2 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.