Sugi Predict

Sugi Predict / Compounds / SCHEMBL5509853

SCHEMBL5509853

SCHEMBL5509853

Cc1ccc2ncc(Br)cc2c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.50
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ MAPT P10636 1/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ HTT P42858 1/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.47
▸ CYP1A2 P05177 4/20 0.47
▸ NCK1 P16333 1/20 0.41
▸ BACE1 P56817 1/20 0.41
▸ CYP2A6 P11509 2/20 0.41
▸ NQO2 P16083 1/20 0.41
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ PSMB5 P28074 1/20 0.40
▸ TNF P01375 1/20 0.38
▸ IKBKB O14920 1/20 0.38
▸ CCR1 P32246 1/20 0.38
▸ CCR5 P51681 1/20 0.38
▸ CCR8 P51685 1/20 0.38
▸ PDE3B Q13370 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5048586 0.84 CYP1A2 (0.57) ALDH1A1SMN1; SMN2MAPTMAPK1HTT
SCHEMBL12958078 0.84 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2MAPTMAPK1HTT
SCHEMBL20528292 0.83 BACE1 (0.47) ALDH1A1SMN1; SMN2MAPTMAPK1HTT
SCHEMBL4572536 0.83 CYP1A2 (0.65) ALDH1A1CYP1A2NCK1BACE1CYP2A6
SCHEMBL24261121 0.76 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2CYP1A2NCK1BACE1
SCHEMBL622744 0.76 EGFR (0.53) ALDH1A1SMN1; SMN2MAPTHTTBACE1
SCHEMBL584342 0.76 BACE1 (0.41) ALDH1A1NPSR1CYP1A2BACE1CYP2A6
SCHEMBL534471 0.76 DYRK1A (0.46) ALDH1A1MAPTHTTMEN1KMT2A
SCHEMBL789944 0.76 PDGFRB (0.39) PDE3BPDE3ADYRK1A
SCHEMBL6438602 0.76 DYRK1A (0.37) ALDH1A1SMN1; SMN2MAPTMAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
EP-4055014-B1 PYRROLIDINE AND PIPERIDINE COMPOUNDS YUHAN CORP (KR) 2025-04-30 — — EP disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
CN-114867719-B Pyrrolidine and piperidine compounds 柳韩洋行 2024-06-25 — — CN disclosed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-11655235-B2 Pyrrolidine and piperidine compounds YUHAN CORPORATION (KR) 2023-05-23 — — US disclosed
EP-4055014-A1 PYRROLIDINE AND PIPERIDINE COMPOUNDS Yuhan Corporation (KR) 2022-09-14 — — EP disclosed
CN-114867719-A Pyrrolidine and piperidine compounds 柳韩洋行 2022-08-05 — — CN disclosed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US disclosed
CN-1373767-A Ketolide antibacterials ORTHO MCNEIL PHARM INC (US) 2002-10-09 — — CN disclosed
US-6458771-B1 SERIES OF KETOLIDE ANTIBACTERIALS IN THE MACROLIDE FAMILY, DRUGS AND INTERMEDIATES, ERYTHROMYCIN ANALOGUES USEFUL IN THE TREATMENT OF BACTERIAL AND PROTOZOAL INFECTIONS AND IN THE TREATMENT OF GASTRIC MOTILITY ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-10-01 — — US disclosed
US-20020119938-A1 Macrolide antiinfective agents CHU DANIEL (US) 2002-08-29 — — US disclosed
US-6399582-B1 GASTROINTESTINAL DISORDERS ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-06-04 — — US disclosed
US-6395710-B1 CONTROLLING INFECTIONS KOSAN BIOSCIENCES, INC. 2002-05-28 — — US disclosed
WO-2002032918-A2 KETOLIDE ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2002-04-25 — — WO disclosed
EP-1171446-A2 MACROLIDE ANTIINFECTIVE AGENTS Kosan Biosciences, Inc. (US) 2002-01-16 — — EP disclosed
EP-1171447-A2 KETOLIDE ANTIBACTERIALS Ortho-McNeil Pharmaceutical, Inc. (US) 2002-01-16 — — EP disclosed
WO-2000063224-A2 MACROLIDE ANTIINFECTIVE AGENTS KOSAN BIOSCIENCES, INC. (US) 2000-10-26 — — WO disclosed
WO-2000062783-A2 KETOLIDE ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2000-10-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A ALDH1A1 110/4885SMN1; SMN2 2299/4885MAPT 3799/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A ALDH1A1 110/4885SMN1; SMN2 2299/4885MAPT 3799/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A ALDH1A1 110/4885SMN1; SMN2 2299/4885MAPT 3799/4885
US-20020119938-A1 Macrolide antiinfective agents MLNR, DOHH, NOP2 ALDH1A1 4432/4885SMN1; SMN2 2499/4885MAPT 4629/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A ALDH1A1 110/4885SMN1; SMN2 2299/4885MAPT 3799/4885
US-11655235-B2 Pyrrolidine and piperidine compounds FAP, APC, VHL ALDH1A1 439/4885SMN1; SMN2 387/4885MAPT 1909/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A ALDH1A1 110/4885SMN1; SMN2 2299/4885MAPT 3799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.