Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31468230 | 0.84 | MALT1 (0.42) | DYRK1ANOS1MALT1KDRCYP2D6 | |
| SCHEMBL10688343 | 0.84 | PDGFRB (0.54) | PDGFRBPDGFRAS1PR3S1PR1ALPL | |
| SCHEMBL20528292 | 0.83 | BACE1 (0.47) | DYRK1ANOS1MALT1 | |
| SCHEMBL22075304 | 0.77 | PTGES (0.35) | PDGFRBPDGFRAS1PR3S1PR1ALPL | |
| SCHEMBL15043760 | 0.76 | ADORA3 (0.39) | PDGFRBPDGFRAPDE3BPDE3AHRH4 | |
| SCHEMBL16288953 | 0.76 | PDGFRB (0.39) | PDGFRBPDGFRAPDE3BPDE3AHRH4 | |
| SCHEMBL534471 | 0.76 | DYRK1A (0.46) | PDGFRBPDGFRAPDE3BPDE3ADYRK1A | |
| SCHEMBL5509853 | 0.76 | ALDH1A1 (0.50) | PDE3BPDE3ADYRK1A | |
| SCHEMBL164336 | 0.76 | DYRK1A (0.54) | PDGFRBPDGFRAPDE3BPDE3AHRH4 | |
| SCHEMBL622744 | 0.76 | EGFR (0.53) | DYRK1AADORA3KDRHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3569596-A1 | 1,2,4-TRIAZINE-3-AMINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2019-11-20 | — | — | EP | disclosed |
| WO-2018130184-A1 | 1,2,4-TRIAZINE-3-AMINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | 江苏恒瑞医药股份有限公司 | 2018-07-19 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| US-7884204-B2 | such as (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinyl)phenyl]propionic acid, used for the teratment of inflammatory diseases, arthritis, inflammatory bowel diseases, lupus, multiple syndrome, asthma, psoriasis, allergies, diabetes and cardiovascular diseases | AJINOMOTO CO., INC. (JP) | 2011-02-08 | — | — | US | disclosed |
| CN-100460415-C | Ketolactones, their use and process for their preparation and pharmaceutical compositions containing them | ABBOTT LAB (US) | 2009-02-11 | — | — | CN | disclosed |
| CN-100441591-C | Ketolactones, their use and process for their preparation and pharmaceutical compositions containing them | ABBOTT LAB (US) | 2008-12-10 | — | — | CN | disclosed |
| US-20080280909-A1 | NEW PHENYLALANINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2008-11-13 | — | — | US | disclosed |
| US-RE39836-E1 | Macrolide antinfective agents | KOSAN BIOSCIENCES, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-7250516-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2007-07-31 | — | — | US | disclosed |
| WO-2000063224-A2 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
| US-6075133-A | INCREASED ACID STABILITY AND ENHANCED BACTERICIDAL ACTIVITY | ABBOTT LABORATORIES (US) | 2000-06-13 | — | — | US | disclosed |
| US-6028181-A | 6-0-Substituted antibacterial erythromycin ketolides and methods of making | ABBOTT LABORATORIES (US) | 2000-02-22 | — | — | US | disclosed |
| CN-1237183-A | 6-0-substituted ketolides with antibacterial activity | ABBOTT CO (US) | 1999-12-01 | — | — | CN | disclosed |
| EP-0929563-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | Abbott Laboratories (US) | 1999-07-21 | — | — | EP | disclosed |
| US-5866549-A | MACROLIDE ANTIBIOTICS | ABBOTT LABORATORIES (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1998009978-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 1998-03-12 | — | — | WO | disclosed |
| US-4738710-A | Herbicidal alkane carboxylic acid derivatives | ICI AUSTRALIA LIMITED (AU) | 1988-04-19 | — | — | US | disclosed |
| EP-0063866-B1 | QUINOLIN-3-YLOXY(AMINO)PHENOXYALKANE CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR SYNTHESIS, HERBICIDAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS HERBICIDES | ICI AUSTRALIA LIMITED (AU) | 1987-12-09 | — | — | EP | disclosed |
| EP-0063866-A1 | Quinolin-3-yloxy(amino)phenoxyalkane carboxylic acid derivatives, process for their synthesis, herbicidal compositions containing them, and their use as herbicides | ICI AUSTRALIA LIMITED (AU) | 1982-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280909-A1 | NEW PHENYLALANINE DERIVATIVES | ITGB4, VCAM1, ITGA4 | PDGFRB 164/4885PDGFRA 411/4885S1PR3 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.