Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4808848 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2GAAALDH1A1HTTHPGD | |
| SCHEMBL9228437 | 0.74 | ALDH1A1 (0.71) | SMN1; SMN2TP53GAAPDE4APDE4B | |
| SCHEMBL10573636 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2TP53GAACASP1PDE4A | |
| SCHEMBL3930133 | 0.71 | PTGS2 (0.37) | SMN1; SMN2ALDH1A1HTTHPGDPKM | |
| SCHEMBL2000387 | 0.70 | CA2 (0.41) | — | |
| SCHEMBL1373329 | 0.70 | PKM (0.35) | GAAALDH1A1HPGDPKMMAPK1 | |
| Bicarbonate SCHEMBL15225613 | 0.69 | GLA (0.68) | SMN1; SMN2TP53GAAPDE4APDE4B | |
| SCHEMBL10577215 | 0.69 | KMT2A (0.61) | SMN1; SMN2TP53GAACASP1PDE4A | |
| SCHEMBL7204094 | 0.68 | PDE4A (0.97) | SMN1; SMN2TP53GAACASP1PDE4A | |
| SCHEMBL9597736 | 0.67 | PTGDR2 (0.40) | SMN1; SMN2GAAALDH1A1HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844011-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006081343-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-03 | — | — | WO | disclosed |