Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1483541 | 0.86 | CYP11B1 (0.46) | CYP11B1CYP11B2TDP1MAPK9ADORA2A | |
| SCHEMBL30431204 | 0.84 | TDP1 (0.62) | CYP11B1CYP11B2TDP1MAPK9ADORA2A | |
| SCHEMBL3711732 | 0.84 | TDP1 (0.62) | CYP11B1CYP11B2TDP1MAPK9ADORA2A | |
| SCHEMBL5511663 | 0.83 | P2RX7 (0.47) | CYP11B1CYP11B2TDP1MAPK9ADORA2A | |
| Hydrochloric Acid SCHEMBL4810594 | 0.83 | TDP1 (0.61) | CYP11B1CYP11B2TDP1MAPK9ADORA2A | |
| SCHEMBL29420689 | 0.78 | TDP1 (0.69) | TDP1 | |
| SCHEMBL1019076 | 0.78 | TDP1 (0.69) | TDP1 | |
| SCHEMBL2258454 | 0.77 | CYP11B1 (0.49) | CYP11B1CYP11B2TDP1ADORA2AADORA1 | |
| SCHEMBL873335 | 0.76 | CYP11B1 (0.47) | CYP11B1CYP11B2TDP1ADORA2AADORA1 | |
| SCHEMBL9646280 | 0.76 | CYP11B2 (0.47) | CYP11B1CYP11B2ADORA2AADORA1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39836-E1 | Macrolide antinfective agents | KOSAN BIOSCIENCES, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-6794366-B2 | ERYTHRONOLIDE DERIVATIVES THAT CONTAIN MODIFICATIONS FROM THE NATIVE STRUCTURE AT POSITIONS 13, E.G., 15-(QUINOL-4-YL-ACETAMIDOERYTHROMYCIN A; BACTERICIDES; PRESERVATIVES | KOSAN BIOSCIENCES, INC. | 2004-09-21 | — | — | US | disclosed |
| US-6762168-B2 | ANTIBACTERIAL COMPOUNDS. THE INVENTION CONCERNS MACROLIDE ANTIBIOTICS USEFUL AS ANTIINFECTIVE AGENTS. | KOSAN BIOSCIENCES, INC. | 2004-07-13 | — | — | US | disclosed |
| US-20030207821-A1 | Macrolide antiinfective agents | CHU DANIEL T W (US) | 2003-11-06 | — | — | US | disclosed |
| US-6593302-B2 | Antibiotics | KOSAN BIOSCIENCES, INC. | 2003-07-15 | — | — | US | disclosed |
| US-6514944-B2 | Macrolide antibiotics containing an erythronolide nucleus modified at least at the substituent at C-13 | KOSAN BIOSCIENCES, INC. | 2003-02-04 | — | — | US | disclosed |
| US-20020156028-A1 | Macrolide antiinfective agents | CHU DANIEL T W (US) | 2002-10-24 | — | — | US | disclosed |
| US-6451768-B1 | Macrolide antiinfective agents | KOSAN BIOSCIENCES, INC. | 2002-09-17 | — | — | US | disclosed |
| US-20020119938-A1 | Macrolide antiinfective agents | CHU DANIEL (US) | 2002-08-29 | — | — | US | disclosed |
| US-6395710-B1 | CONTROLLING INFECTIONS | KOSAN BIOSCIENCES, INC. | 2002-05-28 | — | — | US | disclosed |
| US-20020055472-A1 | Macrolide antiinfective agents | KOSAN BIOSCIENCES, INC. | 2002-05-09 | — | — | US | disclosed |
| EP-1171446-A2 | MACROLIDE ANTIINFECTIVE AGENTS | Kosan Biosciences, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| EP-1171448-A2 | MACROLIDE ANTIINFECTIVE AGENTS | Kosan Biosciences, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2001049699-A1 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2001-07-12 | — | — | WO | disclosed |
| WO-2000063224-A2 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
| WO-2000063225-A2 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156028-A1 | Macrolide antiinfective agents | DOHH, MRPS18B, MRPL21 | CYP11B1 416/4885CYP11B2 574/4885TDP1 4228/4885 |
| US-20020119938-A1 | Macrolide antiinfective agents | MLNR, DOHH, NOP2 | CYP11B1 1580/4885CYP11B2 1611/4885TDP1 4147/4885 |
| US-20030207821-A1 | Macrolide antiinfective agents | BECN1, HSPA5, SQSTM1 | CYP11B1 2434/4885CYP11B2 1917/4885TDP1 3383/4885 |
| US-20020055472-A1 | Macrolide antiinfective agents | BECN1, HSPA5, SQSTM1 | CYP11B1 2434/4885CYP11B2 1917/4885TDP1 3383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.