Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 7/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.46 |
| ▸ | AKT1 | P31749 | 4/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.46 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.46 |
| ▸ | GSK3A | P49840 | 4/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.46 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.46 |
| ▸ | PRKACA | P17612 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5517074 | 1.00 | ROCK1 (0.46) | ROCK1ROCK2GSK3BCLK4RPS6KA5 | |
| SCHEMBL5526282 | 0.88 | CTSL (0.46) | CTSSCTSLCTSKPTGS2MKNK2 | |
| SCHEMBL5526290 | 0.88 | CTSL (0.46) | CTSSCTSLCTSKPTGS2MKNK2 | |
| SCHEMBL5520718 | 0.86 | LMNA (0.43) | MAPK1 | |
| SCHEMBL6170700 | 0.86 | LMNA (0.43) | MAPK1 | |
| SCHEMBL5516794 | 0.84 | CTSK (0.61) | CTSSCTSLCTSBCTSK | |
| SCHEMBL5518307 | 0.84 | CTSK (0.61) | CTSSCTSLCTSBCTSK | |
| SCHEMBL5516415 | 0.84 | CTSK (0.61) | CTSSCTSLCTSBCTSK | |
| SCHEMBL5514720 | 0.84 | CTSK (0.61) | CTSSCTSLCTSBCTSK | |
| SCHEMBL5512613 | 0.83 | P2RX7 (0.41) | CTSSCTSKPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279478-B2 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA & CO. (CA) | 2007-10-09 | — | — | US | disclosed |
| US-20060122268-A1 | Cathepsin cysteine protease inhibitors | MERCK CANADA INC. (CA) | 2006-06-08 | — | — | US | disclosed |
| EP-1537074-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022526-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122268-A1 | Cathepsin cysteine protease inhibitors | CTSB, CTSS, CTSK | ROCK1 2324/4885ROCK2 2936/4885GSK3B 3049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.