Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 7/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP5 | P45974 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | USP3 | Q9Y6I4 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5508768 | 0.91 | USP5 (0.34) | LMNAL3MBTL1USP5MMP3 | |
| SCHEMBL2155666 | 0.85 | KDM4E (0.39) | TP53MAPTLMNACNR1 | |
| SCHEMBL2157126 | 0.81 | DRD2 (0.40) | DRD2MCHR1CCR1TP53MAPT | |
| SCHEMBL2155367 | 0.80 | DRD2 (0.38) | DRD2MCHR1CCR1TP53MAPT | |
| SCHEMBL2154831 | 0.80 | MMP7 (0.36) | DRD2MAPT | |
| SCHEMBL2154992 | 0.80 | LMNA (0.41) | TP53MAPTLMNATSHR | |
| SCHEMBL2155370 | 0.79 | CCR1 (0.44) | MCHR1CCR1USP5 | |
| SCHEMBL16501802 | 0.79 | DRD2 (0.40) | DRD2MCHR1CCR1TP53MAPT | |
| SCHEMBL2156070 | 0.75 | POLB (0.40) | MAPTLMNATSHR | |
| SCHEMBL2155603 | 0.75 | HSD17B10 (0.51) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828160-B1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | MERCK SERONO SA (CH) | 2011-12-14 | — | — | EP | claimed |
| EP-1828160-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | LABORATOIRES SERONO S.A. (CH) | 2007-09-05 | — | — | EP | claimed |
| WO-2006067114-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-06-29 | — | — | WO | claimed |