SCHEMBL552216

SCHEMBL552216

NC(=O)c1cc(Cl)ccc1O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.67
CA2 P00918 1/20 0.67
MAPT P10636 3/20 0.57
PKM P14618 1/20 0.57
ALDH1A1 P00352 3/20 0.56
KDM4E B2RXH2 2/20 0.56
GLA P06280 1/20 0.56
GAA P10253 1/20 0.56
P2RX1 P51575 3/20 0.55
KCNMA1 Q12791 1/20 0.55
TMPRSS4 Q9NRS4 2/20 0.53
P2RX4 Q99571 2/20 0.53
P2RX7 Q99572 2/20 0.53
HPGD P15428 3/20 0.50
HSD17B10 Q99714 3/20 0.50
ALOX15 P16050 2/20 0.50
MAPK1 P28482 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
CHUK O15111 2/20 0.50
MEN1 O00255 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29848306 1.00 CA1 (0.67) CA1CA2MAPTPKMALDH1A1
SCHEMBL5302317 0.84 CHUK (0.67) CA1CA2P2RX1CHUKCLK1
SCHEMBL1071711 0.83 KDM4E (0.52) CA1CA2MAPTPKMALDH1A1
SCHEMBL3790275 0.82 ALDH1A1 (0.60) CA1CA2MAPTALDH1A1KDM4E
SCHEMBL6966672 0.82 CA1 (0.72) CA1CA2MAPTPKMGAA
SCHEMBL23463710 0.81 CA1 (0.55) CA1CA2MAPTPKMALDH1A1
SCHEMBL30219241 0.80 ALDH1A1 (0.65) MAPTALDH1A1KDM4EGLAGAA
SCHEMBL1086528 0.80 ALDH1A1 (0.65) MAPTALDH1A1KDM4EGLAGAA
SCHEMBL29769239 0.80 CA1 (0.69) CA1CA2MAPTPKMP2RX1
5-Chlorosalicylic Acid SCHEMBL130605 0.80 CA1 (1.00) CA1CA2MAPTPKMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 334 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3720493-B1 COMBINATIONS OF RIPK1- AND IKK-INHIBITORS FOR THE PREVENTION OR TREATMENT OF IMMUNE DISEASES UNIV KOELN (DE) 2024-07-24 EP claimed
EP-4093401-A1 SALICYLAMIDE DERIVATIVES AND RELATED METHODS OF MAKING The Board of Regents of the University of Texas System (US) 2022-11-30 EP claimed
CN-114075146-A Preparation method of deferasirox impurity 江苏奥赛康药业有限公司 2022-02-22 CN claimed
EP-1773768-B1 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS INC (US) 2018-08-22 EP claimed
EP-1506196-B1 PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS ICAGEN INC (US) 2012-01-18 EP claimed
EP-1773768-A4 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS INC (US) 2008-08-06 EP claimed
CN-1964939-A Compounds and compositions for delivering active agents EMISPHERE TECH INC (US) 2007-05-16 CN claimed
EP-1773768-A2 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS Exelixis, Inc. (US) 2007-04-18 EP claimed
WO-2006012642-A2 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS, INC. (US) 2006-02-02 WO claimed
CN-1658872-A Antiallergic agent INST MED MOLECULAR DESIGN INC (JP) 2005-08-24 CN claimed
US-20030216593-A1 Method of preparing salicylamides NOVO NORDISK NORTH AMERICA OPERATIONS A/S (DK) 2003-11-20 US claimed
WO-2001092206-A1 METHOD OF PREPARING SALICYLAMIDES EMISPHERE TECHNOLOGIES, INC. (US) 2001-12-06 WO claimed
US-20260071218-A1 Oral Delivery of Antisense Conjugates Targeting PCSK9 CIVI BIOPHARMA INC (US) 2026-03-12 US disclosed
US-20250319056-A1 METHODS FOR TREATING CANCER UNIV INDIANA TRUSTEES (US) 2025-10-16 US disclosed
US-12291708-B2 Oral delivery of antisense conjugates targeting PCSK9 CIVI BIOPHARMA, INC. (US) 2025-05-06 US disclosed
CN-119661464-A Efficient preparation method of chlorzoxazone 山东新时代药业有限公司 2025-03-21 CN disclosed
US-4122049-A Process for the production of polyurethane foam BAYER AKTIENGESELLSCHAFT (DE) 1978-10-24 US disclosed
US-4082751-A ANTIALLERGENS BRISTOL-MYERS COMPANY (US) 1978-04-04 US disclosed
US-4031093-A ANTIALLERGENS BRISTOL-MYERS COMPANY (US) 1977-06-21 US disclosed
US-3968104-A SOLVENTS BAYER AKTIENGESELLSCHAFT (DT) 1976-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260071218-A1 Oral Delivery of Antisense Conjugates Targeting PCSK9 PCSK9, ALPI, SLC10A2 CA1 1982/4885CA2 836/4885MAPT 2115/4885
US-20030216593-A1 Method of preparing salicylamides SCLY, ADSL, SIK3 CA1 129/4885CA2 96/4885MAPT 4132/4885
US-20250319056-A1 METHODS FOR TREATING CANCER HSP90AB1, HSP90B1, HSP90AB2P CA1 2679/4885CA2 2002/4885MAPT 1446/4885
US-12291708-B2 Oral delivery of antisense conjugates targeting PCSK9 PCSK9, SCD5, PCSK7 CA1 2704/4885CA2 1578/4885MAPT 1510/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.