Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5138755 | 0.81 | GPR119 (0.50) | ALDH1A1LMNAHPGDHIF1APROKR1 | |
| SCHEMBL2576253 | 0.80 | MLYCD (0.50) | ALDH1A1LMNAHPGDHSD11B1MCHR1 | |
| SCHEMBL12346561 | 0.79 | HSD11B1 (0.56) | LSSALDH1A1LMNAHPGDHIF1A | |
| SCHEMBL29551553 | 0.78 | PARP1 (0.53) | LSSALDH1A1LMNAHPGDHIF1A | |
| SCHEMBL13416035 | 0.73 | ALDH1A1 (0.53) | LSSALDH1A1LMNAHPGDHIF1A | |
| SCHEMBL24310166 | 0.73 | SLC6A2 (0.54) | LSSSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL12950820 | 0.71 | SLC6A2 (0.55) | LSSALDH1A1PROKR1SLC6A2SLC6A4 | |
| SCHEMBL23469162 | 0.71 | SLC6A2 (0.55) | LSSALDH1A1PROKR1SLC6A2SLC6A4 | |
| SCHEMBL610428 | 0.70 | DRD2 (0.48) | LSSALDH1A1LMNAHPGDHIF1A | |
| SCHEMBL12632280 | 0.70 | PRKAB2 (0.49) | ALDH1A1LMNASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296235-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2014-10-02 | — | — | US | disclosed |
| US-8697736-B2 | 1H-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent PARP inhibitors | ABBVIE INC. (US) | 2014-04-15 | — | — | US | disclosed |
| WO-2012038751-A3 | PROCESS FOR THE PURIFICATION OF AROMATIC DICARBOXYLIC ACID | DAVY PROCESS TECHNOLOGY LIMITED (GB) | 2012-05-10 | — | — | WO | disclosed |
| EP-1957477-B1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBOTT LAB (US) | 2011-12-07 | — | — | EP | disclosed |
| US-20070179136-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296235-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | LSS 2842/4885ALDH1A1 193/4885LMNA 320/4885 |
| US-20070179136-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | LSS 2843/4885ALDH1A1 199/4885LMNA 331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.