Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 6/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31103500 | 0.93 | CAPN9 (0.53) | CES1BCHECAPN9CASP3TGM2 | |
| SCHEMBL15712858 | 0.80 | CAPN9 (0.53) | CES1BCHECAPN9CASP3TGM2 | |
| SCHEMBL8872707 | 0.80 | CES1 (0.62) | CES1BCHECAPN9CASP3TGM2 | |
| SCHEMBL15712304 | 0.80 | CAPN9 (0.53) | CES1BCHECAPN9CASP3TGM2 | |
| SCHEMBL13564439 | 0.80 | CAPN9 (0.53) | CES1BCHECAPN9CASP3TGM2 | |
| SCHEMBL421305 | 0.79 | CYP3A4 (0.50) | ALDH1A1MAPTPKMMAPK1TP53 | |
| SCHEMBL4737998 | 0.78 | CES1 (0.71) | CES1BCHECAPN9CASP3TGM2 | |
| SCHEMBL3303844 | 0.78 | CAPN9 (0.50) | CES1BCHECAPN9CASP3TGM2 | |
| SCHEMBL8555748 | 0.73 | ALDH1A1 (0.40) | CES1BCHECAPN9CASP3ALDH1A1 | |
| SCHEMBL18256571 | 0.72 | CES1 (0.71) | CES1BCHETGM2ALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-17 | — | — | US | disclosed |
| US-20070276025-A1 | Indirubin-Type Compounds, Compositions, and Methods for Their Use | MEIJER LAURENT | 2007-11-29 | — | — | US | disclosed |
| EP-1686988-A1 | INDIRUBIN-TYPE COMPOUNDS, COMPOSITIONS, AND METHODS FOR THEIR USE | THE ROCKEFELLER UNIVERSITY (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005041954-A1 | INDIRUBIN-TYPE COMPOUNDS, COMPOSITIONS, AND METHODS FOR THEIR USE | THE ROCKEFELLER UNIVERSITY (US) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | GPR119, GPR39, GPR65 | CES1 450/4885BCHE 4059/4885CAPN9 3019/4885 |
| US-20070276025-A1 | Indirubin-Type Compounds, Compositions, and Methods for Their Use | CDK3, GSK3B, CDK7 | CES1 1902/4885BCHE 271/4885CAPN9 3403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.