Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 2/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5527850 | 0.89 | KDM4E (0.42) | KDM4EMEN1MAPTKMT2ABTK | |
| SCHEMBL5146830 | 0.80 | ALDH1A1 (0.40) | KDM4EKMT2ABTKPARP1SLC9A1 | |
| SCHEMBL6921914 | 0.80 | KDM4E (0.43) | KDM4EMEN1MAPTKMT2ABTK | |
| SCHEMBL7585953 | 0.71 | SOS1 (0.37) | KDM4EPARP10 | |
| SCHEMBL5140672 | 0.71 | PARP2 (0.40) | KDM4EMEN1KMT2ABTKPARP1 | |
| SCHEMBL1125460 | 0.69 | SOS1 (0.37) | KDM4EMEN1KMT2APARP10 | |
| SCHEMBL5140428 | 0.68 | THRB (0.39) | PARP1KCNH2 | |
| SCHEMBL27903406 | 0.68 | PTGDR2 (0.55) | KDM4EMEN1MAPTKMT2ACAMKK2 | |
| SCHEMBL22867968 | 0.68 | HSD17B2 (0.54) | KDM4EMEN1MAPTKMT2ABTK | |
| SCHEMBL22867965 | 0.67 | ROCK2 (0.43) | KDM4EMEN1MAPTKMT2ACAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | KDM4E 1012/4885MEN1 647/4885MAPT 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.