Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5526973 | 0.83 | SLC6A4 (0.50) | SLC6A3KDM4EALDH1A1MAOBSLC6A4 | |
| SCHEMBL5520748 | 0.81 | CYP3A4 (0.47) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4600032 | 0.81 | EPHX1 (0.41) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL2864888 | 0.79 | MAOA (0.46) | SLC6A3KDM4EALDH1A1MAOBSLC6A4 | |
| SCHEMBL6244722 | 0.77 | MAOA (0.47) | SLC6A3KDM4EALDH1A1MAOBSLC6A4 | |
| SCHEMBL5275909 | 0.76 | HSD11B1 (0.43) | HSD11B1IDO1ALDH1A1HPGDTSHR | |
| SCHEMBL5523971 | 0.76 | ALDH1A1 (0.46) | ALDH1A1TSHRKMT2APOLB | |
| SCHEMBL5075664 | 0.75 | EPHX1 (0.52) | HSD11B1IDO1MAOBMEN1KMT2A | |
| SCHEMBL28475617 | 0.74 | MAOA (0.47) | SLC6A3HSD11B1KDM4EALDH1A1MAOB | |
| SCHEMBL16083425 | 0.74 | OPRM1 (0.47) | HSD11B1IDO1ALDH1A1MAOBTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | SLC6A3 95/4885HSD11B1 561/4885IDO1 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.