Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 8/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5545032 | 0.83 | PTGES (0.39) | PTGESTP53PTGS1ACKR3LMNA | |
| SCHEMBL5546183 | 0.79 | GRM5 (0.44) | PTGESTP53PTGS1LMNAGAA | |
| SCHEMBL5537975 | 0.77 | RXFP1 (0.39) | PTGESTP53RXFP1PTGS1LMNA | |
| SCHEMBL5540374 | 0.74 | CXCR5 (0.38) | PTGESTP53CNR1CNR2LMNA | |
| SCHEMBL5538002 | 0.74 | HCRTR1 (0.40) | PTGESTP53HCRTR1LMNAGAA | |
| SCHEMBL5546875 | 0.67 | MAPT (0.38) | TP53HCRTR1CNR1CNR2LMNA | |
| SCHEMBL5546353 | 0.66 | KEAP1 (0.47) | PTGES | |
| SCHEMBL5546883 | 0.64 | KDM4E (0.40) | TP53RXFP1HCRTR1LMNAGAA | |
| SCHEMBL5546600 | 0.62 | KMT2A (0.40) | TP53LMNA | |
| SCHEMBL6930440 | 0.62 | LMNA (0.63) | PTGESLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |