Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.39 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5544991 | 0.79 | DRD4 (0.39) | DRD4MEN1NPC1RAB9AKMT2A | |
| SCHEMBL5540365 | 0.75 | KMT2A (0.36) | DRD4MCHR1MEN1NPC1RAB9A | |
| SCHEMBL5545011 | 0.74 | NPC1 (0.41) | NPC1RAB9AKMT2A | |
| SCHEMBL5544982 | 0.74 | HPGDS (0.42) | MCHR1MGLL | |
| SCHEMBL5548485 | 0.73 | KMT2A (0.37) | MEN1RAB9AKMT2ACCR1MGLL | |
| SCHEMBL5546833 | 0.72 | FLT1 (0.42) | MEN1NPC1KMT2A | |
| SCHEMBL5546568 | 0.71 | CHRM1 (0.38) | MEN1KMT2A | |
| SCHEMBL5546606 | 0.69 | OPRK1 (0.35) | DRD4MEN1NPC1RAB9AKMT2A | |
| SCHEMBL5540386 | 0.69 | LMNA (0.34) | MEN1NPC1RAB9AKMT2ATDP1 | |
| SCHEMBL5544998 | 0.69 | SIGMAR1 (0.41) | DRD4MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |