Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223922 | 0.75 | NCF1 (0.40) | ALOX5NCF1PIK3CA | |
| SCHEMBL8276483 | 0.70 | DRD2 (0.58) | HTR6HTR2AHTR2CLMNAMAPT | |
| SCHEMBL15007043 | 0.70 | ALOX5 (0.54) | HTR6HTR2AHTR2CPIM1ALOX5 | |
| Hydrochloric Acid SCHEMBL10705356 | 0.69 | ATM (0.59) | HTR6HTR2AHTR2CLMNAMAPT | |
| SCHEMBL900373 | 0.68 | NCF1 (0.62) | HTR6HTR2CPIM1NCF1CYP3A4 | |
| SCHEMBL3594508 | 0.67 | CHRNB2 (0.56) | SLC6A4 | |
| SCHEMBL13271032 | 0.66 | ALDH1A1 (0.56) | PRMT5LMNAMAPTBLMTOP1 | |
| Hydrochloric Acid SCHEMBL1583990 | 0.66 | CHRNB2 (0.54) | SLC6A4 | |
| SCHEMBL3656587 | 0.66 | HTR6 (0.46) | HTR6HTR2AHTR2CLMNAMAPT | |
| SCHEMBL6767507 | 0.66 | ALDH1A1 (0.48) | SLC6A4PIM1PRMT5CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846411-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006081289-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2006-08-03 | — | — | WO | disclosed |