Folescutol

Folescutol

SCHEMBL554577

O=c1cc(CN2CCOCC2)c2cc(O)c(O)cc2o1

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.81
POLB P06746 4/20 0.71
KDM4E B2RXH2 3/20 0.71
HSD17B10 Q99714 5/20 0.64
KMT2A Q03164 6/20 0.63
ALDH1A1 P00352 5/20 0.63
GAA P10253 3/20 0.63
HPGD P15428 3/20 0.63
CASP1 P29466 3/20 0.63
CASP7 P55210 3/20 0.63
GLA P06280 2/20 0.63
SMN1; SMN2 Q16637 1/20 0.63
MEN1 O00255 4/20 0.62
MAPT P10636 1/20 0.59
ERAP1 Q9NZ08 1/20 0.58
MCL1 Q07820 2/20 0.57
TSHR P16473 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
TP53 P04637 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxazorone SCHEMBL2109280 0.84 TDP1 (0.66) TDP1POLBKDM4EHSD17B10KMT2A
Oxazorone SCHEMBL29913823 0.84 TDP1 (0.66) TDP1POLBKDM4EHSD17B10KMT2A
SCHEMBL8708592 0.80 KMT2A (0.64) TDP1POLBKDM4EHSD17B10KMT2A
SCHEMBL30507291 0.79 ALDH1A1 (0.70) TDP1POLBKDM4EHSD17B10KMT2A
SCHEMBL6833560 0.74 MCL1 (0.74) POLBKDM4EHSD17B10KMT2AALDH1A1
SCHEMBL8706801 0.74 MCL1 (1.00) POLBKDM4EHSD17B10KMT2AALDH1A1
SCHEMBL15836637 0.74 KMT2A (1.00) POLBKDM4EHSD17B10KMT2AALDH1A1
SCHEMBL15836702 0.74 KMT2A (0.79) TDP1POLBKDM4EHSD17B10KMT2A
SCHEMBL24589796 0.74 KMT2A (0.66) TDP1POLBKDM4EHSD17B10KMT2A
SCHEMBL8706946 0.72 MCL1 (0.72) TDP1POLBKDM4EHSD17B10KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8026285-B2 Control release of biologically active compounds from multi-armed oligomers BEZWADA BIOMEDICAL, LLC (US) 2011-09-27 US claimed
US-20090076174-A1 CONTROL RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS BEZWADA BIOMEDICAL, LLC (US) 2009-03-19 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-3356440-B1 HYDROPHOBIC HIGHLY BRANCHED CARBOHYDRATE POLYMERS PURDUE RESEARCH FOUNDATION (US) 2024-06-05 EP disclosed
US-20220257770-A1 HYDROPHOBIC HIGHLY BRANCHED CARBOHYDRATE POLYMERS PURDUE RESEARCH FOUNDATION (US) 2022-08-18 US disclosed
US-11052153-B2 Highly branched alpha-D-glucans PURDUE RESEARCH FOUNDATION (US) 2021-07-06 US disclosed
US-20200268894-A1 HYDROPHOBIC HIGHLY BRANCHED CARBOHYDRATE POLYMERS PURDUE RESEARCH FOUNDATION (US) 2020-08-27 US disclosed
US-10689330-B2 Amino acid derivatives and absorbable polymers therefrom BEZWADA BIOMEDICAL, LLC (US) 2020-06-23 US disclosed
US-20200165192-A1 AMINO ACID DERIVATIVES AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL LLC (US) 2020-05-28 US disclosed
US-10653784-B2 Hydrophobic highly branched carbohydrate polymers PURDUE RESEARCH FOUNDATION (US) 2020-05-19 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN disclosed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP disclosed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO disclosed
EP-0878549-A2 Process for the enzymatic production of fructosylated compounds Chemisches Laboratorium Dr. Kurt Richter GmbH (DE) 1998-11-18 EP disclosed
WO-1993016064-A1 COUMARIN DERIVATIVES AND THEIR ANALOGUES INHIBITING CELL PROLIFERATION AND TUMOUR GROWTH, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME BIOSIGNAL, Kutató-Fejleszto^' Kft. (HU) 1993-08-19 WO disclosed
US-4705779-A Pharmaceutical compositions of anti-pancreatic inflammatory effect BIOGAL GYOGYSZERGYAR OF DEBRECEN AND ALKALOIDA VEGYESZETI GYAR OF TISZAVASVARI (HU) 1987-11-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10653784-B2 Hydrophobic highly branched carbohydrate polymers HACD3, ALG1, HACD2 TDP1 4255/4885POLB 3423/4885KDM4E 4796/4885
US-20090076174-A1 CONTROL RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS MME, CTSA, ALG1 TDP1 971/4885POLB 1563/4885KDM4E 3828/4885
US-20200268894-A1 HYDROPHOBIC HIGHLY BRANCHED CARBOHYDRATE POLYMERS HACD3, ALG1, HACD2 TDP1 4255/4885POLB 3423/4885KDM4E 4796/4885
US-10689330-B2 Amino acid derivatives and absorbable polymers therefrom SRRM2, SLC7A1, BCAT2 TDP1 1961/4885POLB 4422/4885KDM4E 2679/4885
US-20200165192-A1 AMINO ACID DERIVATIVES AND ABSORBABLE POLYMERS THEREFROM SRRM2, SLC7A1, BCAT2 TDP1 1961/4885POLB 4422/4885KDM4E 2679/4885
US-20220257770-A1 HYDROPHOBIC HIGHLY BRANCHED CARBOHYDRATE POLYMERS HACD3, ALG1, HACD2 TDP1 4255/4885POLB 3423/4885KDM4E 4796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.