Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.43 |
| ▸ | POLB | P06746 | 7/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 2/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5052040 | 0.82 | L3MBTL1 (0.47) | L3MBTL1POLBTDP1KDM4EMAPT | |
| SCHEMBL18920540 | 0.76 | MYC (0.53) | L3MBTL1POLBTDP1KDM4EMAPT | |
| SCHEMBL5530847 | 0.70 | KDM4E (0.55) | TDP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL27840902 | 0.69 | KEAP1 (0.46) | L3MBTL1POLBTDP1KDM4EMAPT | |
| SCHEMBL27596775 | 0.68 | PTPN1 (0.47) | L3MBTL1POLBTDP1KDM4EMAPT | |
| SCHEMBL28869121 | 0.67 | PTPN1 (0.52) | L3MBTL1POLBTDP1KDM4EMAPT | |
| SCHEMBL18920575 | 0.67 | KEAP1 (0.44) | L3MBTL1POLBTDP1KDM4EALDH1A1 | |
| SCHEMBL5489960 | 0.67 | KDM4E (0.50) | POLBTDP1KDM4EMAPTALDH1A1 | |
| SCHEMBL9305599 | 0.67 | KDM4E (0.55) | TDP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL30753447 | 0.66 | ALDH1A1 (0.47) | KDM4EMAPTALDH1A1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781610-A2 | ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE | CELGENE CORPORATION (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006015060-A2 | ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE | CELGENE CORPORATION (US) | 2006-02-09 | — | — | WO | disclosed |