Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.50 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5535046 | 0.95 | TSHR (0.50) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| SCHEMBL5542243 | 0.94 | KCNH2 (0.49) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| SCHEMBL5535033 | 0.94 | KCNH2 (0.49) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| SCHEMBL88305 | 0.90 | TSHR (0.55) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| SCHEMBL378396 | 0.82 | TSHR (0.58) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| SCHEMBL1895864 | 0.81 | TSHR (0.51) | TSHRSIGMAR1 | |
| SCHEMBL67263 | 0.81 | TSHR (0.49) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| SCHEMBL27783167 | 0.81 | TSHR (0.49) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| SCHEMBL18913824 | 0.80 | TSHR (0.69) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| SCHEMBL30758863 | 0.80 | TSHR (0.69) | TSHRKCNH2KCNJ1IDO1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040235022-A1 | Quality control method for manufacturing biopolymer arrays | ROCHE DIAGNOSTICS GMBH (DE) | 2004-11-25 | — | — | US | claimed |
| EP-1466663-A1 | Quality control method for manufacturing nucleic acid arrays | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-13 | — | — | EP | claimed |
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
| US-6852752-B2 | Urea compounds, compositions and methods of use and preparation | VICURON PHARMACEUTICALS INC. (US) | 2005-02-08 | — | — | US | disclosed |
| US-20040235022-A1 | Quality control method for manufacturing biopolymer arrays | ROCHE DIAGNOSTICS GMBH (DE) | 2004-11-25 | — | — | US | disclosed |
| EP-1466663-A1 | Quality control method for manufacturing nucleic acid arrays | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-13 | — | — | EP | disclosed |
| US-6797820-B2 | HYDROXAMATE DERIVATIVES THAT INHIBIT PEPTIDYL DEFORMYLASE (PDF), ANTIMICROBIALS AND ANTIBIOTICS | VICURON PHARMACEUTICALS INC. | 2004-09-28 | — | — | US | disclosed |
| EP-1237862-A1 | SUCCINATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE AND PREPARATION | Versicor, Inc. (US) | 2002-09-11 | — | — | EP | disclosed |
| US-20020119962-A1 | Novel urea compounds, compositions and methods of use and preparation | VICURON HOLDINGS LLC | 2002-08-29 | — | — | US | disclosed |
| US-20020115863-A1 | Novel succinate compounds, compositions and methods of use and preparation | VICURON HOLDINGS LLC | 2002-08-22 | — | — | US | disclosed |
| US-20010053555-A1 | METHODS FOR SOLID-PHASE SYNTHESIS OF HYDROXYLAMINE COMPOUNDS AND DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | VERSICOR, INC. | 2001-12-20 | — | — | US | disclosed |
| US-6281245-B1 | ADMINISTERING DEFORMYLASE INHIBITOR | VERSICOR, INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001044178-A1 | NOVEL UREA COMPOUNDS, COMPOSITIONS AND METHODS OF USE AND PREPARATION | VERSICOR, INC. (US) | 2001-06-21 | — | — | WO | disclosed |
| WO-2001044179-A1 | NOVEL SUCCINATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE AND PREPARATION | VERSICOR, INC. (US) | 2001-06-21 | — | — | WO | disclosed |
| WO-1999057097-A2 | METHODS FOR SOLID-PHASE SYNTHESIS OF HYDROXYLAMINE COMPOUNDS AND DERIVATIVES, AND COMBINATORIAL LIBRARIES THEREOF | VERSICOR, INC. (US) | 1999-11-11 | — | — | WO | disclosed |
| WO-1998018754-A1 | METHODS FOR SOLID-PHASE SYNTHESIS OF HYDROXYLAMINE COMPOUNDS AND DERIVATIVES, AND COMBINATORIAL LIBRARIES THEREOF | VERSICOR, INC. (US) | 1998-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | TSHR 319/4885KCNH2 3503/4885KCNJ1 3581/4885 |
| US-20020115863-A1 | Novel succinate compounds, compositions and methods of use and preparation | PDF, MMP2, SDHA | TSHR 4589/4885KCNH2 4789/4885KCNJ1 4527/4885 |
| US-20020119962-A1 | Novel urea compounds, compositions and methods of use and preparation | PDF, UROD, HDHD5 | TSHR 3464/4885KCNH2 4651/4885KCNJ1 4294/4885 |
| US-20010053555-A1 | METHODS FOR SOLID-PHASE SYNTHESIS OF HYDROXYLAMINE COMPOUNDS AND DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | HNMT, HAAO, HPSE | TSHR 1868/4885KCNH2 3937/4885KCNJ1 4482/4885 |
| US-20040235022-A1 | Quality control method for manufacturing biopolymer arrays | CTRL, PCBP1, PARG | TSHR 4430/4885KCNH2 3985/4885KCNJ1 4614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.