Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.47 |
| ▸ | PLA2G10 | O15496 | 8/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.40 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.40 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.40 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.40 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.40 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.40 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28681774 | 0.89 | PLA2G2A (0.57) | PLA2G2APLA2G10USP2ALDH1A1MAPT | |
| SCHEMBL5482150 | 0.86 | PLA2G2A (0.45) | PLA2G2APLA2G10IDH1USP2ALDH1A1 | |
| SCHEMBL6528867 | 0.83 | ALDH1A1 (0.42) | PLA2G2APLA2G10IDH1USP2ALDH1A1 | |
| SCHEMBL10318607 | 0.81 | ALDH1A1 (0.44) | PLA2G2APLA2G10IDH1USP2ALDH1A1 | |
| SCHEMBL28778955 | 0.80 | PLA2G2A (0.47) | PLA2G2APLA2G10USP2ALDH1A1MAPT | |
| SCHEMBL28778944 | 0.80 | MAPT (0.48) | PLA2G2APLA2G10ALDH1A1MAPTHPGD | |
| SCHEMBL4937860 | 0.80 | PLA2G2A (0.44) | PLA2G2APLA2G10IDH1USP2ALDH1A1 | |
| SCHEMBL5482149 | 0.78 | MYC (0.47) | PLA2G2APLA2G10IDH1USP2ALDH1A1 | |
| SCHEMBL7204828 | 0.78 | IDH1 (0.47) | IDH1ALDH1A1HTTLMNA | |
| SCHEMBL2326693 | 0.78 | PLA2G2A (0.45) | PLA2G2APLA2G10IDH1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1862181-A2 | Combination therapy using an 11B-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders | NOVO NORDISK A/S (DK) | 2007-12-05 | — | — | EP | claimed |
| CN-111039813-B | Synthetic method of aromatic amide compound | 江南大学 | 2022-07-01 | — | — | CN | disclosed |
| CN-111039813-A | Synthetic method of aromatic amide compound | 江南大学 | 2020-04-21 | — | — | CN | disclosed |
| EP-1862181-A2 | Combination therapy using an 11B-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders | NOVO NORDISK A/S (DK) | 2007-12-05 | — | — | EP | disclosed |
| EP-1854487-A2 | Combinations of an 11-beta-hydroxysteroid dehaydrogenase type 1 inhibitor and a glucocorticoid receptor agonist | Novo Nordisk A/S (DK) | 2007-11-14 | — | — | EP | disclosed |