Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238588 | 0.75 | OPRM1 (0.42) | ALDH1A1RAB9A | |
| SCHEMBL7203556 | 0.73 | CHRNB2 (0.48) | ALDH1A1CHRNB2CHRNA4NISCHCYP1A2 | |
| SCHEMBL18253192 | 0.70 | ALDH1A1 (0.65) | ALDH1A1ACACBCYP1A2MGAMPDGFRB | |
| SCHEMBL8647723 | 0.69 | ALDH1A1 (0.46) | ALDH1A1 | |
| SCHEMBL5115607 | 0.69 | GRM5 (0.46) | CHRNB2CHRNA4CYP1A2MAP3K14 | |
| SCHEMBL7214768 | 0.69 | ALDH1A1 (0.63) | ALDH1A1ACACBCYP1A2MGAMPDGFRB | |
| SCHEMBL4818276 | 0.69 | ALDH1A1 (0.63) | ALDH1A1ACACBCYP1A2MGAMKDM4E | |
| SCHEMBL63442 | 0.68 | ALDH1A1 (0.57) | ALDH1A1NISCHCYP1A2MGAMKDM4E | |
| Water SCHEMBL27871202 | 0.68 | ALDH1A1 (0.57) | ALDH1A1NISCHCYP1A2MGAMKDM4E | |
| SCHEMBL29788946 | 0.68 | ALDH1A1 (0.57) | ALDH1A1NISCHCYP1A2MGAMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838672-A1 | 4-PIPERIDINOL TERTIARY AMINES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF OBESITY AND OTHER CNS DISORDERS | Athersys, Inc. (US) | 2007-10-03 | — | — | EP | claimed |
| WO-2006071750-A1 | 4-PIPERIDINOL TERTIARY AMINES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF OBESITY AND OTHER CNS DISORDERS | ATHERSYS, INC. (US) | 2006-07-06 | — | — | WO | claimed |