Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534462 | 1.00 | MAPT (0.40) | MAPTSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL555812 | 1.00 | MAPT (0.40) | MAPTSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL533861 | 0.72 | REN (0.45) | MAPTSMN1; SMN2CYP1A2CYP2C19POLB | |
| SCHEMBL533862 | 0.72 | REN (0.45) | MAPTSMN1; SMN2CYP1A2CYP2C19POLB | |
| SCHEMBL9786763 | 0.70 | MAPT (0.46) | MAPTSMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL534491 | 0.67 | SPR (0.37) | MAPTKDM4ETSHRMAPK1 | |
| Brosuximide SCHEMBL2109189 | 0.62 | ALDH1A1 (0.60) | MAPTSMN1; SMN2KDM4EPOLBL3MBTL1 | |
| SCHEMBL15647651 | 0.61 | MAPT (0.50) | MAPTSMN1; SMN2KDM4EPOLBL3MBTL1 | |
| SCHEMBL534280 | 0.61 | IDO1 (0.37) | IDO1RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL156842 | 0.61 | CHRNB2 (0.56) | MAPTSMN1; SMN2KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | MAPT 4208/4885SMN1; SMN2 4604/4885KDM4E 2653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.