Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560260 | 0.98 | PTGS2 (0.37) | PTGS2HSD11B1CYP19A1MEN1KMT2A | |
| SCHEMBL5822674 | 0.92 | PTGS2 (0.36) | PTGS2CYP19A1FAAHMGLLAKR1C3 | |
| SCHEMBL5819680 | 0.91 | PTGS2 (0.37) | PTGS2CYP19A1FAAHMGLLAKR1C3 | |
| SCHEMBL5559333 | 0.90 | PTGS2 (0.43) | PTGS2AKR1C3AKR1C2 | |
| SCHEMBL5800295 | 0.90 | TSHR (0.36) | PTGS2HSD11B1CYP19A1SLC22A12ALDH1A1 | |
| SCHEMBL5801342 | 0.89 | PTGS2 (0.35) | PTGS2HSD11B1CYP19A1MEN1KMT2A | |
| SCHEMBL5819926 | 0.89 | L3MBTL1 (0.37) | PTGS2HSD11B1ALDH1A1 | |
| SCHEMBL5822711 | 0.89 | LMNA (0.39) | HSD11B1MEN1KMT2AALDH1A1AKR1C3 | |
| SCHEMBL5798701 | 0.88 | PTGS2 (0.45) | PTGS2CYP19A1AKR1C3AKR1C2 | |
| SCHEMBL5800554 | 0.88 | PTGS2 (0.38) | PTGS2HSD11B1CYP19A1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006050120-A2 | SYNTHESIS OF COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |