Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 6/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554125 | 0.98 | PTGS2 (0.38) | PTGS2PDE4BPDE4DHSD11B1PPARG | |
| SCHEMBL5801005 | 0.89 | PTGS2 (0.44) | PTGS2 | |
| SCHEMBL5800052 | 0.88 | PTGS2 (0.39) | PTGS2PDE4BPDE4DHSD11B1PPARG | |
| SCHEMBL5796692 | 0.87 | PTGS2 (0.37) | PTGS2HSD11B1MGLL | |
| SCHEMBL5559471 | 0.87 | PTGS2 (0.42) | PTGS2 | |
| SCHEMBL5813198 | 0.87 | PTGS2 (0.41) | PTGS2PDE4BPDE4DHSD11B1PPARG | |
| SCHEMBL5801148 | 0.87 | HSD11B1 (0.38) | PTGS2PDE4BPDE4DHSD11B1PPARG | |
| SCHEMBL5560483 | 0.86 | PPARG (0.36) | PTGS2PPARGPPARA | |
| SCHEMBL5559153 | 0.86 | TSHR (0.36) | PTGS2HSD11B1 | |
| SCHEMBL5801342 | 0.85 | PTGS2 (0.35) | PTGS2HSD11B1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |