Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | PTPRC | P08575 | 1/20 | 0.49 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560042 | 0.93 | MAOA (0.64) | MAOAMAPTSMN1; SMN2EGFRPABPC1 | |
| SCHEMBL11875820 | 0.81 | MEN1 (0.65) | MAOAPTPRCMAPTSMN1; SMN2PABPC1 | |
| SCHEMBL7818784 | 0.78 | MAOA (0.87) | MAOAPTPRCPTPN13MAPTSMN1; SMN2 | |
| SCHEMBL6849448 | 0.77 | MAOA (0.59) | MAOAMAPTSMN1; SMN2EGFRPABPC1 | |
| SCHEMBL6852445 | 0.77 | MAOA (0.56) | MAOAPTPRCPTPN13MAPTSMN1; SMN2 | |
| SCHEMBL4123519 | 0.77 | MAPT (0.56) | MAOAPTPRCPTPN13MAPTSMN1; SMN2 | |
| SCHEMBL11656337 | 0.77 | MAOA (0.64) | MAOAPTPRCPTPN13MAPTSMN1; SMN2 | |
| SCHEMBL28044169 | 0.77 | MAOA (0.64) | MAOAMAPTSMN1; SMN2EGFRPABPC1 | |
| SCHEMBL4862664 | 0.75 | PARP14 (0.42) | MAOAMAPTPABPC1MAPK1RAB9A | |
| SCHEMBL20892849 | 0.75 | MAOA (0.62) | MAOAPTPRCPTPN13MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689705-A4 | FUSED RING DICATIONIC ANTI-PROTOZOAN AGENTS AND THEIR PRODRUGS | UNIV NORTH CAROLINA (US) | 2007-08-29 | — | — | EP | disclosed |
| EP-1689705-A2 | FUSED RING DICATIONIC ANTI-PROTOZOAN AGENTS AND THEIR PRODRUGS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005051296-A2 | FUSED RING DICATIONIC ANTI-PROTOZOAN AGENTS AND THEIR PRODRUGS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-06-09 | — | — | WO | disclosed |