Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.59 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Cresol SCHEMBL1904230 | 0.82 | ACHE (0.59) | ACHELMNAMEN1KMT2AMAPT | |
| Alcohol SCHEMBL3952222 | 0.80 | ACHE (0.72) | ACHETEAD4LMNAMEN1KMT2A | |
| Alcohol SCHEMBL28542951 | 0.80 | ACHE (0.56) | ACHETEAD4LMNAMEN1KMT2A | |
| SCHEMBL15362252 | 0.80 | CYP1A2 (0.41) | ACHELMNAMEN1KMT2ACYP1A2 | |
| Tromethamine SCHEMBL5702541 | 0.80 | LMNA (0.43) | ACHELMNAMEN1KMT2ATDP1 | |
| Tromethamine SCHEMBL3104874 | 0.80 | LMNA (0.43) | ACHELMNAMEN1KMT2ATDP1 | |
| Tromethamine SCHEMBL7181961 | 0.80 | LMNA (0.43) | ACHELMNAMEN1KMT2ATDP1 | |
| 4,4'-Methylenedianiline SCHEMBL1759256 | 0.77 | CYP3A4 (0.64) | LMNAMEN1KMT2ATDP1ALDH1A1 | |
| Methyl Alcohol SCHEMBL28213590 | 0.77 | ACHE (0.87) | ACHETEAD4LMNAMEN1KMT2A | |
| SCHEMBL8469646 | 0.77 | ACHE (1.00) | ACHETEAD4MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1623010-A4 | PRESERVATION OF RNA IN A BIOLOGICAL SAMPLE | JANSSEN PHARMACEUTICA NV (BE) | 2007-12-26 | — | — | EP | disclosed |
| EP-1623010-A2 | PRESERVATION OF RNA IN A BIOLOGICAL SAMPLE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096984-A2 | PRESERVATION OF RNA IN A BIOLOGICAL SAMPLE | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-11-11 | — | — | WO | disclosed |
| EP-0643847-B1 | ELECTROPHOTOGRAPHIC MATERIAL CONTAINING PARTICULAR PHTHALOCYANINES | AGFA GEVAERT NV (BE) | 1996-11-27 | — | — | EP | disclosed |
| EP-0429116-B1 | Photoconductive recording material with special outermost layer | AGFA GEVAERT NV (BE) | 1995-03-22 | — | — | EP | disclosed |
| EP-0643846-A1 | PHOTOCONDUCTIVE RECORDING MATERIAL COMPRISING A CROSS-LINKED BINDER SYSTEM | AGFA-GEVAERT N.V. (BE) | 1995-03-22 | — | — | EP | disclosed |
| EP-0643847-A1 | ELECTROPHOTOGRAPHIC MATERIAL CONTAINING PARTICULAR PHTHALOCYANINES. | AGFA GEVAERT NV (BE) | 1995-03-22 | — | — | EP | disclosed |
| EP-0428209-B1 | Photoconductive recording material with special outermost layer | AGFA GEVAERT NV (BE) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024862-A1 | PHOTOCONDUCTIVE RECORDING MATERIAL COMPRISING A CROSS-LINKED BINDER SYSTEM | AGFA-GEVAERT NAAMLOZE VENNOOTSCHAP (BE) | 1993-12-09 | — | — | WO | disclosed |
| WO-1993024865-A1 | ELECTROPHOTOGRAPHIC MATERIAL CONTAINING PARTICULAR PHTHALOCYANINES | AGFA-GEVAERT NAAMLOZE VENNOOTSCHAP (BE) | 1993-12-09 | — | — | WO | disclosed |
| US-5208128-A | Multilayer element with polysiloxane block copolymers with aromatic polyesters or carbonates | AGFA-GEVAERT, N.V. (BE) | 1993-05-04 | — | — | US | disclosed |
| US-5208127-A | Multilayer element with polysiloxane block copolymers with aromatic polyesters or carbonates | AGFA-GEVAERT, N.V. (BE) | 1993-05-04 | — | — | US | disclosed |
| EP-0429116-A1 | Photoconductive recording material with special outermost layer | AGFA-GEVAERT N.V. (BE) | 1991-05-29 | — | — | EP | disclosed |
| EP-0428209-A1 | Photoconductive recording material with special outermost layer | AGFA-GEVAERT N.V. (BE) | 1991-05-22 | — | — | EP | disclosed |