Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | HTR1B | P28222 | 2/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3902735 | 0.86 | HSD11B1 (0.46) | ALDH1A1HSD11B1POLBAPEX1CTDSP1 | |
| SCHEMBL9470357 | 0.86 | HSD11B1 (0.46) | ALDH1A1HSD11B1POLBCXCR2CA1 | |
| SCHEMBL11689461 | 0.83 | ALDH1A1 (0.56) | ALDH1A1POLBAPEX1CTDSP1L3MBTL1 | |
| SCHEMBL3198514 | 0.82 | ALDH1A1 (0.51) | ALDH1A1HSD11B1CXCR2KDM4EHSD17B10 | |
| SCHEMBL5569165 | 0.80 | HSD11B1 (0.47) | ALDH1A1HSD11B1CXCR2CA1CA2 | |
| SCHEMBL11779341 | 0.80 | ALDH1A1 (0.58) | ALDH1A1POLBAPEX1CTDSP1L3MBTL1 | |
| SCHEMBL3181925 | 0.80 | KDM4E (0.49) | ALDH1A1HSD11B1L3MBTL1CXCR2HTR1A | |
| SCHEMBL6551724 | 0.79 | HSD11B1 (0.46) | HSD11B1CXCR2CA1CA2CXCR1 | |
| SCHEMBL3201334 | 0.79 | ALDH1A1 (0.53) | ALDH1A1HSD11B1CXCR2CXCR1KDM4E | |
| SCHEMBL903987 | 0.78 | KDM4E (0.45) | ALDH1A1HSD11B1POLBKDM4EAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312249-B2 | Vitamin D analogues | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-12-25 | — | — | US | disclosed |
| EP-1537065-B1 | ANALOGUES OF VITAMIN D | GALDERMA RES & DEV (FR) | 2006-11-02 | — | — | EP | disclosed |
| US-20050182144-A1 | Novel vitamin D analogues | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182144-A1 | Novel vitamin D analogues | CYP24A1, CYP2R1, VDR | ALDH1A1 121/4885HSD11B1 51/4885POLB 3120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.