Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP5 | P45974 | 1/20 | 0.66 |
| ▸ | HSD17B3 | P37058 | 8/20 | 0.65 |
| ▸ | HTR7 | P34969 | 1/20 | 0.62 |
| ▸ | STS | P08842 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30871980 | 0.95 | HSD17B3 (0.66) | USP5HSD17B3HTR7STSL3MBTL1 | |
| SCHEMBL17281117 | 0.92 | USP5 (0.57) | USP5HSD17B3HTR7STSL3MBTL1 | |
| SCHEMBL4871741 | 0.90 | USP5 (0.72) | USP5HSD17B3HTR7L3MBTL1MEN1 | |
| SCHEMBL11464173 | 0.89 | USP5 (0.70) | USP5HSD17B3HTR7STSL3MBTL1 | |
| SCHEMBL17281116 | 0.87 | USP5 (0.55) | USP5HSD17B3HTR7STSL3MBTL1 | |
| SCHEMBL30089581 | 0.86 | USP5 (0.85) | USP5HSD17B3L3MBTL1MEN1KMT2A | |
| SCHEMBL14522305 | 0.86 | HSD17B3 (0.83) | HSD17B3HTR7STSL3MBTL1NPC1 | |
| SCHEMBL11484918 | 0.86 | HSD17B3 (0.61) | USP5HSD17B3HTR7STSL3MBTL1 | |
| SCHEMBL28522367 | 0.84 | HSD17B3 (0.59) | USP5HSD17B3HTR7STSL3MBTL1 | |
| SCHEMBL2923903 | 0.84 | USP5 (0.64) | USP5HSD17B3HTR7L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745004-B1 | ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2016-05-18 | — | — | EP | disclosed |
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-03-08 | — | — | US | disclosed |
| US-20100137605-A1 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100010227-A1 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| EP-1745004-A4 | ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2007-05-09 | — | — | EP | disclosed |
| EP-1745004-A2 | ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | Emisphere Technologies, Inc. (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005117854-A2 | ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | NR0B1, GRK7, NR5A2 | USP5 2098/4885HSD17B3 745/4885HTR7 919/4885 |
| US-20100137605-A1 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES | HPD, PTMA, HAAO | USP5 742/4885HSD17B3 1450/4885HTR7 511/4885 |
| US-20100010227-A1 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES | DDC, HPD, ALDH7A1 | USP5 757/4885HSD17B3 1990/4885HTR7 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.