Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.85 |
| ▸ | POLB | P06746 | 1/20 | 0.85 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077865 | 0.98 | HPGD (0.97) | HPGDKMT2APOLBTSHRGAA | |
| Biphenyl SCHEMBL27927640 | 0.85 | POLB (0.86) | HPGDKMT2APOLBTSHRGAA | |
| SCHEMBL3323307 | 0.85 | HPGD (0.74) | HPGDKMT2APOLBTSHRGAA | |
| SCHEMBL13746309 | 0.85 | POLB (0.81) | HPGDKMT2APOLBTSHRGAA | |
| SCHEMBL13923294 | 0.82 | TSHR (0.69) | HPGDKMT2APOLBTSHRGAA | |
| SCHEMBL15528616 | 0.81 | HPGD (0.67) | HPGDKMT2APOLBKDM4EMEN1 | |
| SCHEMBL22640183 | 0.79 | HPGD (0.65) | HPGDKMT2APOLBTSHRGAA | |
| SCHEMBL6076562 | 0.78 | KMT2A (0.75) | HPGDKMT2APOLBTSHRNPC1 | |
| SCHEMBL6076593 | 0.77 | HPGD (1.00) | HPGDKMT2APOLBTSHRNPC1 | |
| SCHEMBL22365557 | 0.77 | HPGD (0.62) | HPGDKMT2APOLBTSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003099812-A1 | PHENYL-FURAN OR PHENYL-THIOPHENE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINE | PIERRE FABRE MEDICAMENT (FR) | 2003-12-04 | — | — | WO | claimed |
| US-20190135718-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2019-05-09 | — | — | US | disclosed |
| US-20170305824-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2017-10-26 | — | — | US | disclosed |
| US-9586880-B2 | Small molecule inhibitors of necroptosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-03-07 | — | — | US | disclosed |
| EP-3000468-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | President and Fellows of Harvard College (US) | 2016-03-30 | — | — | EP | disclosed |
| US-20140024657-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-01-23 | — | — | US | disclosed |
| US-20120122889-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-17 | — | — | US | disclosed |
| WO-2010075561-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122889-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | TNF, TNFRSF1A, RIPK1 | HPGD 2009/4885KMT2A 3609/4885POLB 2233/4885 |
| US-20170305824-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | TNF, TNFRSF1A, RIPK1 | HPGD 2102/4885KMT2A 3648/4885POLB 2287/4885 |
| US-20190135718-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | TNF, TNFRSF1A, RIPK1 | HPGD 2102/4885KMT2A 3648/4885POLB 2287/4885 |
| US-20140024657-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | TNF, TNFRSF1A, RIPK1 | HPGD 2102/4885KMT2A 3648/4885POLB 2287/4885 |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | HSD3B1, HSD3B2, HSD11B1 | HPGD 330/4885KMT2A 3083/4885POLB 1708/4885 |
| US-20100120789-A1 | Compound | NR0B2, NR0B1, NR4A1 | HPGD 3581/4885KMT2A 2533/4885POLB 3372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.