Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TYR | P14679 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | CTRC | Q99895 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832727 | 0.98 | ALOX5 (0.40) | TDP1ALOX5CYP3A4TYRMEN1 | |
| SCHEMBL1268563 | 0.94 | TDP1 (0.39) | TDP1ALOX5CYP3A4TYRMEN1 | |
| SCHEMBL7832945 | 0.86 | TDP1 (0.41) | TDP1 | |
| SCHEMBL30951372 | 0.82 | TDP1 (0.39) | TDP1 | |
| SCHEMBL2877727 | 0.81 | TLR8 (0.47) | TLR8 | |
| SCHEMBL7829368 | 0.80 | TLR8 (0.40) | TDP1ALOX5CYP3A4TYRMEN1 | |
| SCHEMBL27325471 | 0.80 | TDP1 (0.40) | TDP1 | |
| SCHEMBL23748091 | 0.78 | TDP1 (0.39) | TDP1TLR8 | |
| SCHEMBL31426179 | 0.78 | TDP1 (0.43) | TDP1 | |
| SCHEMBL30951365 | 0.78 | TDP1 (0.39) | TDP1TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180346470-A1 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2018-12-06 | — | — | US | disclosed |
| EP-3386983-A1 | 4-(BIPHEN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZINE DERIVATIVES OF FORMULA (I) AS GABA RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF EPILEPSY AND PAIN | Pfizer Limited (GB) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017098367-A1 | 4-(BIPHEN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZINE DERIVATIVES OF FORMULA (I) AS GABA RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF EPILEPSY AND PAIN | PFIZER LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |
| US-7300932-B2 | Pyrrolo[1,2-b]pyridazine derivatives | JAPAN TOBACCO INC. (JP) | 2007-11-27 | — | — | US | disclosed |
| EP-1653969-A4 | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES | JAPAN TOBACCO INC (JP) | 2006-12-20 | — | — | EP | disclosed |
| EP-1653969-A2 | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES | Japan Tabacco Inc. (JP) | 2006-05-10 | — | — | EP | disclosed |
| US-20050070545-A1 | For treatment or prevention of metabolic and cell proliferative diseases; modifying lipid metabolism | TULARIK INC. (US) | 2005-03-31 | — | — | US | disclosed |
| WO-2005013907-A2 | PYRROLO[1,2-B]PYRIDAZINE DERIVATIVES | JAPAN TOBACCO INC. (JP) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070545-A1 | For treatment or prevention of metabolic and cell proliferative diseases; modifying lipid metabolism | PC, ACACB, ACAT1 | TDP1 3788/4885ALOX5 385/4885CYP3A4 3957/4885 |
| US-20180346470-A1 | CHEMICAL COMPOUNDS | P2RX5, GABRA5, P2RX3 | TDP1 1934/4885ALOX5 852/4885CYP3A4 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.