Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29460883 | 1.00 | SIGMAR1 (0.43) | SIGMAR1ADRA2AADRA2BADRA2CCDK5 | |
| SCHEMBL3987657 | 0.98 | SIGMAR1 (0.41) | SIGMAR1ADRA2AADRA2BADRA2CCDK5 | |
| SCHEMBL3988316 | 0.98 | SIGMAR1 (0.41) | SIGMAR1ADRA2AADRA2BADRA2CCDK5 | |
| SCHEMBL19450166 | 0.98 | SIGMAR1 (0.41) | SIGMAR1ADRA2AADRA2BADRA2CCDK5 | |
| SCHEMBL2946238 | 0.98 | SIGMAR1 (0.41) | SIGMAR1ADRA2AADRA2BADRA2CCDK5 | |
| SCHEMBL2940094 | 0.98 | SIGMAR1 (0.41) | SIGMAR1ADRA2AADRA2BADRA2CCDK5 | |
| SCHEMBL19450091 | 0.98 | SIGMAR1 (0.41) | SIGMAR1ADRA2AADRA2BADRA2CCDK5 | |
| SCHEMBL29438246 | 0.95 | — | — | |
| SCHEMBL35277 | 0.95 | — | — | |
| SCHEMBL9536810 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 520 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11117887-B2 | Aryl substituted pyrimidines for use in influenza virus infection | Janssen Sciences Ireland Unlimited Company (IE) | 2021-09-14 | — | — | US | claimed |
| CN-113260609-A | Aromatic receptor antagonists and methods of use thereof | 美真达治疗公司 | 2021-08-13 | — | — | CN | claimed |
| US-20210220408-A1 | ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND METHODS OF USE | EDIGENE BIOTECHNOLOGY, INC. (CN) | 2021-07-22 | — | — | US | claimed |
| EP-3847159-A2 | ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND METHODS OF USE | Magenta Therapeutics, Inc. (US) | 2021-07-14 | — | — | EP | claimed |
| US-20120035190-A1 | E-type Phenyl Acrylic Ester Compounds Containing Substituted Anilino Pyrimidine Group and Uses Thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2012-02-09 | — | — | US | claimed |
| US-20100130495-A1 | COMPOUNDS 563 | ASTRAZENECA AB (SE) | 2010-05-27 | — | — | US | claimed |
| US-7544691-B2 | Guanidine derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2009-06-09 | — | — | US | claimed |
| EP-1663993-B1 | GUANIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-03-12 | — | — | EP | claimed |
| US-20070123510-A1 | Guanidine derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-05-31 | — | — | US | claimed |
| JP-2007504176-A | — | — | 2007-03-01 | — | — | JP | claimed |
| CN-1148383-A | Heterocyclylamino-and heterocyclyloxy-cycloalkyl derivatives, their preparation and their use as pesticides and fungicides | HOECHST SCHERING AGREVO GMBH (DE) | 1997-04-23 | — | — | CN | claimed |
| EP-0759909-A1 | HETEROCYCLYLAMINO- AND HETEROCYCLYLOXY-CYCLOALKYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PESTICIDES AND FUNGICIDES | Hoechst Schering AgrEvo GmbH (DE) | 1997-03-05 | — | — | EP | claimed |
| US-5571815-A | Substituted pyrimidines, process for their preparation, and their use as pesticides and fungicides | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-11-05 | — | — | US | claimed |
| CN-1130904-A | Substituted pyridines and pyrimidines, method for the production thereof and use thereof as pesticides and fungicides | HOECHST SCHERING AGREVO GMBH (DE) | 1996-09-11 | — | — | CN | claimed |
| EP-0719259-A1 | SUBSTITUTED PYRIDINES AND PYRIMIDINES, PROCESS FOR PRODUCING THEM AND THEIR USE AS PESTICIDES AND FUNGICIDES | Hoechst Schering AgrEvo GmbH (DE) | 1996-07-03 | — | — | EP | claimed |
| WO-1995031441-A1 | HETEROCYCLYLAMINO- AND HETEROCYCLYLOXY-CYCLOALKYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PESTICIDES AND FUNGICIDES | HOECHST SCHERING AGREVO GMBH (DE) | 1995-11-23 | — | — | WO | claimed |
| WO-1995007894-A1 | SUBSTITUTED PYRIDINES AND PYRIMIDINES, PROCESS FOR PRODUCING THEM AND THEIR USE AS PESTICIDES AND FUNGICIDES | HOECHST SCHERING AGREVO GMBH (DE) | 1995-03-23 | — | — | WO | claimed |
| EP-0631575-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS PESTICIDES | Hoechst Schering AgrEvo GmbH (DE) | 1995-01-04 | — | — | EP | claimed |
| WO-1993019050-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS PESTICIDES | HOECHST SCHERING AGREVO GMBH (DE) | 1993-09-30 | — | — | WO | claimed |
| CN-1076692-A | Substituted pyrimidines, their production and use as pesticides and fungicides | HOECHST AG (DE) | 1993-09-29 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11117887-B2 | Aryl substituted pyrimidines for use in influenza virus infection | HPRT1, TYMP, PNP | SIGMAR1 1727/4885ADRA2A 1221/4885ADRA2B 661/4885 |
| US-20070123510-A1 | Guanidine derivatives | NPFFR1, NPFFR2, OGFR | SIGMAR1 705/4885ADRA2A 381/4885ADRA2B 343/4885 |
| US-20100130495-A1 | COMPOUNDS 563 | BACE1, PSEN1, PSEN2 | SIGMAR1 4403/4885ADRA2A 286/4885ADRA2B 198/4885 |
| US-20210220408-A1 | ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND METHODS OF USE | AHR, ARNT, ARSA | SIGMAR1 556/4885ADRA2A 165/4885ADRA2B 185/4885 |
| US-20120035190-A1 | E-type Phenyl Acrylic Ester Compounds Containing Substituted Anilino Pyrimidine Group and Uses Thereof | ATIC, DDT, GART | SIGMAR1 3280/4885ADRA2A 2901/4885ADRA2B 1920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.