Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PLK1 | P53350 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652368 | 0.80 | NPC1 (0.50) | HPGDKMT2AHSD17B10MEN1SMN1; SMN2 | |
| SCHEMBL1559659 | 0.79 | KMT2A (0.65) | HPGDTSHRKMT2AHSD17B10MEN1 | |
| SCHEMBL1534502 | 0.78 | RAB9A (0.61) | HPGDKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL23714659 | 0.77 | GAA (0.53) | HPGDTSHRKMT2AALDH1A1GAA | |
| SCHEMBL31743116 | 0.77 | APEX1 (0.49) | HPGDKMT2AHSD17B10MEN1SMN1; SMN2 | |
| SCHEMBL11445475 | 0.77 | ALDH1A1 (0.49) | HPGDHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL16454332 | 0.77 | MTNR1A (0.48) | HPGDKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL24252069 | 0.74 | NR1H4 (0.59) | HPGDHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL4774740 | 0.74 | PLK1 (0.50) | HPGDTSHRHSD17B10SMN1; SMN2GAA | |
| SCHEMBL4460479 | 0.74 | SMN1; SMN2 (0.43) | HPGDTSHRKMT2AHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668841-A1 | SUBSTITUTED BENZIMIDAZOLES AS POTASSIUM CHANNEL INHIBITORS | Acesion Pharma ApS (DK) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019034603-A1 | SUBSTITUTED BENZIMIDAZOLES AS POTASSIUM CHANNEL INHIBITORS | ACESION PHARMA APS (DK) | 2019-02-21 | — | — | WO | disclosed |
| EP-1838674-A2 | HETEROARYL SULFONAMIDES AND CCR2 | ChemoCentryx Inc (US) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006076644-A2 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX, INC. (US) | 2006-07-20 | — | — | WO | disclosed |