Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | NQO2 | P16083 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL559386 | 0.92 | ALDH1A1 (0.62) | ALDH1A1NQO2MAPTLMNARAB9A | |
| SCHEMBL6844954 | 0.79 | CYP1A2 (0.54) | ALDH1A1NQO2MAPTLMNARAB9A | |
| SCHEMBL29639043 | 0.79 | CYP1A2 (0.54) | ALDH1A1NQO2MAPTLMNARAB9A | |
| SCHEMBL29580471 | 0.79 | ALDH1A1 (0.55) | ALDH1A1MAPTLMNARAB9ASMN1; SMN2 | |
| SCHEMBL346120 | 0.79 | ALDH1A1 (0.55) | ALDH1A1MAPTLMNARAB9ASMN1; SMN2 | |
| Toluene SCHEMBL28417697 | 0.79 | ALDH1A1 (0.51) | ALDH1A1NQO2MAPTLMNARAB9A | |
| Ammonia Solution, Strong SCHEMBL28148393 | 0.78 | ALDH1A1 (0.53) | ALDH1A1MAPTLMNARAB9ASMN1; SMN2 | |
| SCHEMBL6216217 | 0.77 | ALDH1A1 (1.00) | ALDH1A1NQO2MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL780275 | 0.76 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL12647372 | 0.76 | ALDH1A1 (0.52) | ALDH1A1RAB9ASMN1; SMN2NPC1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101735158-B | Preparation method of 2, 3-dimercapto-6-methylquinoxaline | NANJING UNIVERSITY OF TECHNOLOGY | 2011-08-31 | — | — | CN | claimed |
| CN-101735158-A | Preparation method of 2, 3-dimercapto-6-methylquinoxaline | NANJING UNIVERSITY OF TECHNOLOGY | 2010-06-16 | — | — | CN | claimed |
| WO-2020065613-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-02 | — | — | WO | disclosed |
| CN-108191778-A | It treats different things alike the method for preparing 2,3- dichloro-quinoxaline derivatives | 重庆医科大学 | 2018-06-22 | — | — | CN | disclosed |
| CN-108084425-A | Makrolon and preparation method thereof, polycarbonate compositions or blend and its application | 万华化学集团股份有限公司 | 2018-05-29 | — | — | CN | disclosed |
| US-9822108-B2 | Antimicrobial agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-11-21 | — | — | US | disclosed |
| US-9822108-B2 | Antimicrobial agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-11-21 | — | — | US | disclosed |
| US-9822108-B2 | Antimicrobial agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-11-21 | — | — | US | disclosed |
| US-20160101104-A1 | QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | BRISTOL MYERS SQUIBB CO (US) | 2016-04-14 | — | — | US | disclosed |
| US-20150342935-A1 | QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | BRISTOL MYERS SQUIBB CO (US) | 2015-12-03 | — | — | US | disclosed |
| CN-103524436-B | 1-[(the alkoxyl group quinoxalinyl that 6,7-replaces) aminocarboxyl]-4-(mixing) aryl piperazine derivative | REXAHN PHARMACEUTICALS INC. (US) | 2015-09-23 | — | — | CN | disclosed |
| CN-101903372-A | Heteroaryl derivatives as orexin receptor antagonists | HOFFMANN LA ROCHE | 2010-12-01 | — | — | CN | disclosed |
| CN-101735158-A | Preparation method of 2, 3-dimercapto-6-methylquinoxaline | NANJING UNIVERSITY OF TECHNOLOGY | 2010-06-16 | — | — | CN | disclosed |
| US-20100099684-A1 | Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands | BRISTOL-MYERS SQUIBB COMPANY | 2010-04-22 | — | — | US | disclosed |
| US-20090270405-A1 | QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY | 2009-10-29 | — | — | US | disclosed |
| WO-2009131926-A1 | QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-10-29 | — | — | WO | disclosed |
| WO-2007087250-A2 | TRICYCLIC INHIBITORS OF 5-LIPOXYGENASE | AMIRA PHARMACEUTICALS, INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| US-20070173508-A1 | TRICYCLIC INHIBITORS OF 5-LIPOXYGENASE | AMIRA PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
| US-20070173508-A1 | TRICYCLIC INHIBITORS OF 5-LIPOXYGENASE | AMIRA PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
| EP-0046468-A1 | Quinoxaline derivatives and herbicidal composition | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1982-03-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099684-A1 | Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands | CHRNA7, CHRNA5, CHRNA6 | ALDH1A1 1082/4885NQO2 130/4885MAPT 268/4885 |
| US-20070173508-A1 | TRICYCLIC INHIBITORS OF 5-LIPOXYGENASE | ALOX5, ALOX15, ALOX15B | ALDH1A1 802/4885NQO2 649/4885MAPT 4706/4885 |
| US-20090270405-A1 | QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | CHRNA7, CHRNA5, CHRNA6 | ALDH1A1 1082/4885NQO2 130/4885MAPT 268/4885 |
| US-20160101104-A1 | QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | CHRNA7, CHRNA5, CHRNA6 | ALDH1A1 1082/4885NQO2 130/4885MAPT 268/4885 |
| US-20150342935-A1 | QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | CHRNA7, CHRNA5, CHRNA6 | ALDH1A1 1082/4885NQO2 130/4885MAPT 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.