Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14710910 | 0.89 | ANO1 (0.52) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL14788524 | 0.89 | KDM4E (0.62) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL30142386 | 0.89 | KDM4E (0.62) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6527669 | 0.88 | ALDH1A1 (0.69) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL28923320 | 0.86 | L3MBTL1 (0.51) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL30142351 | 0.86 | L3MBTL1 (0.51) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL28302118 | 0.86 | KDM4E (0.63) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL11732285 | 0.86 | L3MBTL1 (0.55) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL31314572 | 0.86 | RAB9A (0.70) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7068281 | 0.86 | L3MBTL1 (0.67) | KDM4EALDH1A1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| CN-104478837-B | A kind of preparation method of 2-arylbenzofuran-3-formic acid compound | 中科院广州化学有限公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-104478837-A | Preparation method of 2-arylbenzofuran-3-formic acid compound | CAS GUANGZHOU CHEMISTRY CO LTD | 2015-04-01 | — | — | CN | disclosed |
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | disclosed |
| EP-0147044-B1 | BENZOFURANCARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | ADRIA LABORATORIES INC. (US) | 1990-04-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | KDM4E 3495/4885ALDH1A1 4193/4885HPGD 2346/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | KDM4E 3117/4885ALDH1A1 4421/4885HPGD 2414/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | KDM4E 3495/4885ALDH1A1 4193/4885HPGD 2346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.