Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK2 | O00142 | 2/20 | 0.66 |
| ▸ | TYMP | P19971 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PYGM | P11217 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16042095 | 1.00 | TK2 (0.66) | TK2TYMPALDH1A1LMNAALB | |
| SCHEMBL5414718 | 0.90 | TK2 (0.64) | TK2TYMPALDH1A1LMNAALB | |
| SCHEMBL6512561 | 0.90 | TK2 (0.64) | TK2TYMPALDH1A1LMNAALB | |
| SCHEMBL62322 | 0.89 | TK2 (0.67) | TK2TYMPALDH1A1LMNAALB | |
| SCHEMBL20875706 | 0.89 | TK2 (0.67) | TK2TYMPALDH1A1LMNAALB | |
| SCHEMBL22992424 | 0.89 | TK2 (0.67) | TK2TYMPALDH1A1LMNAALB | |
| SCHEMBL62321 | 0.89 | TK2 (0.67) | TK2TYMPALDH1A1LMNAALB | |
| SCHEMBL22992480 | 0.89 | TK2 (0.67) | TK2TYMPALDH1A1LMNAALB | |
| SCHEMBL7182936 | 0.89 | TK2 (0.67) | TK2TYMPALDH1A1LMNAALB | |
| SCHEMBL1021637 | 0.89 | TK2 (0.67) | TK2TYMPALDH1A1LMNAALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070232798-A1 | Process For The Synthesis Of 2'-O-Substituted Pyrimidines And Oligomeric Compounds Therefrom | COOK PHILLIP D | 2007-10-04 | — | — | US | disclosed |
| US-20050059815-A1 | Processes for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom | COOK PHILLIP DAN (US) | 2005-03-17 | — | — | US | disclosed |
| US-6642367-B2 | Oligonucleotide sfor use in the treatment of cancer and viral diseases | ISIS PHARMACEUTICALS, INC. | 2003-11-04 | — | — | US | disclosed |
| US-20030050454-A1 | Process for the synthesis of 2' -O-substituted pyrimidines and oligomeric compounds therefrom | ISIS PHARMACEUTICALS, INC. | 2003-03-13 | — | — | US | disclosed |
| EP-0813539-A4 | IMPROVED PROCESS FOR THE SYNTHESIS OF 2'-O-SUBSTITUTED PYRIMIDINES AND OLIGOMERIC COMPOUNDS THEREFROM | ISIS PHARMACEUTICALS INC (US) | 2002-01-23 | — | — | EP | disclosed |
| US-6222025-B1 | OLIGONUCLEOTIDES HAVING 2' AND 5 SUBSTITUTED PYRIMIDINE NUCLEOTIDES; INCREASED AFFINITY FOR NUCLEIC ACIDS; INCREASED NUCLEASE RESISTANCE | ISIS PHARMACEUTICALS, INC. | 2001-04-24 | — | — | US | disclosed |
| US-6166197-A | Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions | ISIS PHARMACEUTICALS, INC. (US) | 2000-12-26 | — | — | US | disclosed |
| EP-0813539-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF 2'-O-SUBSTITUTED PYRIMIDINES AND OLIGOMERIC COMPOUNDS THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1996027606-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF 2'-O-SUBSTITUTED PYRIMIDINES AND OLIGOMERIC COMPOUNDS THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 1996-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059815-A1 | Processes for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom | NUDT1, DPYD, UMPS | TK2 34/4885TYMP 20/4885ALDH1A1 842/4885 |
| US-20070232798-A1 | Process For The Synthesis Of 2'-O-Substituted Pyrimidines And Oligomeric Compounds Therefrom | TYMS, RRM2, ATIC | TK2 39/4885TYMP 12/4885ALDH1A1 1105/4885 |
| US-20030050454-A1 | Process for the synthesis of 2' -O-substituted pyrimidines and oligomeric compounds therefrom | ATIC, TYMS, RRM2 | TK2 37/4885TYMP 12/4885ALDH1A1 940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.