SCHEMBL5580490

SCHEMBL5580490

OC/C=C/c1ccc(-c2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 2/20 0.53
CA1 P00915 1/20 0.53
HDAC2 Q92769 3/20 0.48
ALDH1A1 P00352 2/20 0.48
CYP3A4 P08684 1/20 0.48
RECQL P46063 1/20 0.48
GRIK1 P39086 1/20 0.47
GRIK2 Q13002 1/20 0.47
HDAC1 Q13547 3/20 0.46
HDAC6 Q9UBN7 2/20 0.46
PAM P19021 1/20 0.45
TP53 P04637 1/20 0.44
MMP3 P08254 1/20 0.41
BCL2L1 Q07817 1/20 0.41
IDO1 P14902 2/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5580493 1.00 MGLL (0.53) MGLLCA1HDAC2ALDH1A1CYP3A4
Biphenyl SCHEMBL21402589 0.93 PAM (0.52) MGLLCA1HDAC2ALDH1A1CYP3A4
Biphenyl SCHEMBL21402588 0.93 PAM (0.52) MGLLCA1HDAC2ALDH1A1CYP3A4
Cinnamic Alcohol SCHEMBL27887623 0.86 PAM (0.58) CA1HDAC2ALDH1A1CYP3A4RECQL
Cinnamic Alcohol SCHEMBL39220 0.86 PAM (0.58) CA1HDAC2ALDH1A1CYP3A4RECQL
Cinnamic Alcohol SCHEMBL891462 0.86 PAM (0.58) CA1HDAC2ALDH1A1CYP3A4RECQL
Cinnamic Alcohol SCHEMBL28583889 0.86 PAM (0.58) CA1HDAC2ALDH1A1CYP3A4RECQL
Cinnamic Alcohol SCHEMBL4175503 0.86 PAM (0.58) CA1HDAC2ALDH1A1CYP3A4RECQL
Cinnamic Alcohol SCHEMBL39219 0.86 PAM (0.58) CA1HDAC2ALDH1A1CYP3A4RECQL
Cinnamic Alcohol SCHEMBL28671087 0.84 PAM (0.56) CA1HDAC2ALDH1A1CYP3A4RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113135816-A Method for synthesizing photoactive bromohydrin compound 常州大学 2021-07-20 CN disclosed
CN-108947754-B Use of bidentate phosphite ligands in C-F bond building reactions 郑州大学 2021-02-26 CN disclosed
US-10202410-B2 Scaphopetalone analogs and their uses BRIGHAM YOUNG UNIVERSITY (US) 2019-02-12 US disclosed
US-20170152280-A1 SCAPHOPETALONE ANALOGS AND THEIR USES BRIGHAM YOUNG UNIVERSITY 2017-06-01 US disclosed
US-20170152280-A1 SCAPHOPETALONE ANALOGS AND THEIR USES BRIGHAM YOUNG UNIVERSITY 2017-06-01 US disclosed
US-20170107180-A1 GLYCOSIDASE INHIBITORS AND USES THEREOF MERCK SHARP & DOHME CORP. 2017-04-20 US disclosed
US-20150299122-A1 GLYCOSIDASE INHIBITORS AND USES THEREOF ALECTOS THERAPEUTICS INC. (CA) 2015-10-22 US disclosed
US-20070105959-A1 Cynnamyl alcohol derivative compounds and drugs containing the compounds as active ingredient ONO PHARMACEUTICAL CO., LTD. (JP) 2007-05-10 US disclosed
US-7067530-B2 Compounds, their preparation and use NOVO NORDISK A/S (DK) 2006-06-27 US disclosed
EP-1604971-A1 CINNAMYL ALCOHOL DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 2005-12-14 EP disclosed
US-6867218-B2 Compounds, their preparation and use NOVO NORDISK A/S (DK) 2005-03-15 US disclosed
US-20030195200-A1 Compounds, their preparation and use VTVX HOLDINGS II LLC 2003-10-16 US disclosed
US-20030109560-A1 Novel compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC 2003-06-12 US disclosed
US-6555577-B1 For treatment and/or prevention of conditions mediated by the Peroxisome Proliferator-Activated Receptors (PPAR), such as diabetes and/or obesity; 3-(4-(3-Biphenyl-4-yl-but-2-enyloxy)-phenyl)-2-butoxy-propionic acid for example NOVO NORDISK A/S (DE) 2003-04-29 US disclosed
EP-1254101-A1 PROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF DIABETES AND OBESITY Novo Nordisk A/S (DK) 2002-11-06 EP disclosed
WO-2001055085-A1 PROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF DIABETES AND OBESITY NOVO NORDISK A/S (DK) 2001-08-02 WO disclosed
US-3995054-A MITICIDES ZOECON CORPORATION (US) 1976-11-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10202410-B2 Scaphopetalone analogs and their uses MUSK, SHBG, CYP17A1 MGLL 1181/4885CA1 4412/4885HDAC2 4603/4885
US-20150299122-A1 GLYCOSIDASE INHIBITORS AND USES THEREOF OGA, ENGASE, OGT MGLL 900/4885CA1 1702/4885HDAC2 388/4885
US-20070105959-A1 Cynnamyl alcohol derivative compounds and drugs containing the compounds as active ingredient LPL, GPR119, EBP MGLL 39/4885CA1 4800/4885HDAC2 444/4885
US-20030195200-A1 Compounds, their preparation and use PPARG, PPARA, PPARD MGLL 862/4885CA1 4184/4885HDAC2 1111/4885
US-20170152280-A1 SCAPHOPETALONE ANALOGS AND THEIR USES MUSK, SHBG, CYP17A1 MGLL 1181/4885CA1 4412/4885HDAC2 4603/4885
US-20170107180-A1 GLYCOSIDASE INHIBITORS AND USES THEREOF OGA, ENGASE, OGT MGLL 900/4885CA1 1702/4885HDAC2 388/4885
US-20030109560-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA MGLL 792/4885CA1 4613/4885HDAC2 897/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.