SCHEMBL558100

SCHEMBL558100

CC(=O)Nc1ccc2nc(N)sc2c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LDHA P00338 2/20 0.71
EPHX2 P34913 3/20 0.67
RAB9A P51151 8/20 0.61
NPC1 O15118 6/20 0.61
MAPT P10636 5/20 0.61
SMN1; SMN2 Q16637 3/20 0.61
ALDH1A1 P00352 3/20 0.61
KDM4E B2RXH2 3/20 0.61
MEN1 O00255 2/20 0.61
KMT2A Q03164 2/20 0.61
POLB P06746 1/20 0.61
PKM P14618 1/20 0.61
ILK Q13418 1/20 0.59
LMNA P02545 2/20 0.59
GAA P10253 1/20 0.57
HPGD P15428 1/20 0.57
HTT P42858 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
RECQL P46063 1/20 0.56
CSNK2A2 P19784 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11770131 0.88 CLK1 (0.57) LDHAEPHX2RAB9ANPC1MAPT
SCHEMBL30136375 0.86 EPHX2 (0.68) LDHAEPHX2RAB9ANPC1MAPT
SCHEMBL24104135 0.86 EPHX2 (0.68) LDHAEPHX2RAB9ANPC1MAPT
SCHEMBL6067867 0.85 EPHX2 (0.59) LDHAEPHX2RAB9ANPC1MAPT
SCHEMBL11348023 0.85 MAPT (0.64) LDHAEPHX2RAB9ANPC1MAPT
SCHEMBL9722829 0.84 RAB9A (0.64) LDHAEPHX2RAB9ANPC1MAPT
SCHEMBL3923955 0.83 LDHA (1.00) LDHARAB9ANPC1MAPTSMN1; SMN2
SCHEMBL3098809 0.82 LDHA (0.68) LDHARAB9ANPC1MAPTSMN1; SMN2
SCHEMBL1747915 0.82 LDHA (0.71) LDHAEPHX2RAB9ANPC1MAPT
SCHEMBL2340714 0.82 LDHA (0.71) LDHARAB9ANPC1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118027341-B Yellowing-resistant polyurethane for polishing pad and preparation process thereof 上海鹤城高分子科技有限公司 2024-12-06 CN claimed
CN-118027341-A Yellowing-resistant polyurethane for polishing pad and preparation process thereof 上海鹤城高分子科技有限公司 2024-05-14 CN claimed
US-20100234377-A1 PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE EVOTEC AG (DE) 2010-09-16 US claimed
EP-2150532-A1 PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE Evotec AG (DE) 2010-02-10 EP claimed
WO-2008122787-A1 PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE EVOTEC AG (DE) 2008-10-16 WO claimed
EP-0272212-B1 PROCESS FOR CONTINUALLY PRODUCING AZO OR HYDRAZONE DYES CIBA-GEIGY AG (CH) 1993-09-01 EP claimed
US-12404283-B2 c-MYC mRNA translation modulators and uses thereof in the treatment of cancer ANIMA BIOTECH INC. (US) 2025-09-02 US disclosed
EP-4547672-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER Anima Biotech Inc. (US) 2025-05-07 EP disclosed
US-20250129100-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2025-04-24 US disclosed
CN-119233976-A Modulators of c-MYC mRNA translation and their use in the treatment of cancer 艾尼莫生物科技公司 2024-12-31 CN disclosed
CN-118027341-B Yellowing-resistant polyurethane for polishing pad and preparation process thereof 上海鹤城高分子科技有限公司 2024-12-06 CN disclosed
CN-118027341-A Yellowing-resistant polyurethane for polishing pad and preparation process thereof 上海鹤城高分子科技有限公司 2024-05-14 CN disclosed
WO-2024010762-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2024-01-11 WO disclosed
US-4051084-A BENZOTHIAZOLE BAYER AKTIENGESELLSCHAFT (DT) 1977-09-27 US disclosed
US-4039526-A PRINTING, POLYACRYLONITRILE, POLYESTERS, POLYAMIDES BAYER AKTIENGESELLSCHAFT (DT) 1977-08-02 US disclosed
US-4009294-A Process of preparing fire-retardant natural and synthetic fibers HERCULES INCORPORATED (US) 1977-02-22 US disclosed
US-4006127-A Cationic diazacyanine dyestuffs BAYER AKTIENGESELLSCHAFT (DT) 1977-02-01 US disclosed
US-3991042-A Basic azo dyestuffs containing a benzthiazole and a tetrahydroquinoline nucleus BAYER AKTIENGESELLSCHAFT (DT) 1976-11-09 US disclosed
US-3957835-A BROMINATED AZIDO FIRE RETARDANTS HERCULES INCORPORATED (US) 1976-05-18 US disclosed
US-3948877-A POLYACRYLONITRILE, ACID MODIFIED POLYESTERS OR POLYAMIDES BAYER AKTIENGESELLSCHAFT (DT) 1976-04-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250129100-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 LDHA 3342/4885EPHX2 4815/4885RAB9A 2519/4885
US-20100234377-A1 PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE HPGDS, PTGDR, PTGIS LDHA 2026/4885EPHX2 381/4885RAB9A 2884/4885
US-12404283-B2 c-MYC mRNA translation modulators and uses thereof in the treatment of cancer MYC, MYCBP, MYCBP2 LDHA 3342/4885EPHX2 4815/4885RAB9A 2519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.