Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.67 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.67 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.60 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.55 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.55 |
| ▸ | BLM | P54132 | 3/20 | 0.55 |
| ▸ | GABRR3 | A8MPY1 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.40 |
| ▸ | GABRP | O00591 | 3/20 | 0.38 |
| ▸ | GABRD | O14764 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4204452 | 1.00 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Fumaric Acid SCHEMBL558298 | 1.00 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Glycine SCHEMBL558371 | 0.89 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Glycine SCHEMBL558369 | 0.89 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Crotonic Acid SCHEMBL28145066 | 0.83 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Maleic Acid SCHEMBL18065037 | 0.83 | TSHR (0.64) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Maleic Acid SCHEMBL786851 | 0.83 | TSHR (0.64) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Fumaric Acid SCHEMBL2840791 | 0.83 | TSHR (0.64) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Fumaric Acid SCHEMBL18065038 | 0.83 | TSHR (0.64) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Fumaric Acid SCHEMBL786567 | 0.83 | TSHR (0.64) | GLRA1SLC6A9OR51E2TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357533-B2 | Drug for the effective control of acute and or chronic pain and a method for its administration | PVP LaBs PTE, Ltd. (SG) | 2019-07-23 | — | — | US | claimed |
| US-20190225587-A1 | INDAZOLYL- AND INDOLYL-BENZAMIDE DERIVATIVES | ESANEX, INC. | 2019-07-25 | — | — | US | disclosed |
| US-20120035320-A1 | POLYACRIDINE NUCLEIC ACID DELIVERY PEPTIDE COMPLEXES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035320-A1 | POLYACRIDINE NUCLEIC ACID DELIVERY PEPTIDE COMPLEXES | NUP205, PABPC1, SARNP | GLRA1 2509/4885SLC6A9 1530/4885OR51E2 2564/4885 |
| US-20190225587-A1 | INDAZOLYL- AND INDOLYL-BENZAMIDE DERIVATIVES | IDO2, MKI67, IDO1 | GLRA1 3846/4885SLC6A9 4574/4885OR51E2 4438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.